中华眼外伤职业眼病杂志
中華眼外傷職業眼病雜誌
중화안외상직업안병잡지
CHINESE JOURNAL OF OCULAR TRAUMA AND OCCUPATIONAL EYE DISEASE
2014年
9期
676-679
,共4页
钱道卫%郭海科%廖燕秋%伍岚
錢道衛%郭海科%廖燕鞦%伍嵐
전도위%곽해과%료연추%오람
生长因子,成纤维细胞,碱性%异物,角膜%泪膜
生長因子,成纖維細胞,堿性%異物,角膜%淚膜
생장인자,성섬유세포,감성%이물,각막%루막
Factor,growth,fibroblast,recombinant%Body,foreign,corneal%Film,tear
目的 探讨重组牛碱性成纤维细胞生长因子(r-bFGF)滴眼液对角膜异物剔除术后泪膜动态变化的影响.方法 临床病例治疗对照研究.角膜异物剔除术127例(127眼),随机分为治疗组(r-bFGF+氧氟沙星治疗组65例)、对照组(氧氟沙星治疗组,62例).在术前、术后3d、术后5d进行泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)及角膜荧光素染色(FL)检查.结果 两组患者术前上述3项检查结果无差异(BUTt=0.148,P=0.883;SIt t=0.173,P=0.863;FLt=0.730,P=0.467).术后3d两组BUT、FL都有恢复,治疗组恢复明显,两组间差异有统计学意义(BUTt=3.050,P=0.003;FLt=-6.934P=0.000),术后5d两组间BUT差异无统计学意义(t=1.407,P=0.162).术后SIt较术前缩短,术后3d两组间差异有统计学意义(t=-4.825,P=0.000)、术后5d两组间差异无统计学意义(t=1.507,P=0.134).结论 角膜异物剔除术后使用r-bFGF有利于促进角膜上皮的修复,恢复泪膜的稳定性.
目的 探討重組牛堿性成纖維細胞生長因子(r-bFGF)滴眼液對角膜異物剔除術後淚膜動態變化的影響.方法 臨床病例治療對照研究.角膜異物剔除術127例(127眼),隨機分為治療組(r-bFGF+氧氟沙星治療組65例)、對照組(氧氟沙星治療組,62例).在術前、術後3d、術後5d進行淚膜破裂時間(BUT)、基礎淚液分泌試驗(SIt)及角膜熒光素染色(FL)檢查.結果 兩組患者術前上述3項檢查結果無差異(BUTt=0.148,P=0.883;SIt t=0.173,P=0.863;FLt=0.730,P=0.467).術後3d兩組BUT、FL都有恢複,治療組恢複明顯,兩組間差異有統計學意義(BUTt=3.050,P=0.003;FLt=-6.934P=0.000),術後5d兩組間BUT差異無統計學意義(t=1.407,P=0.162).術後SIt較術前縮短,術後3d兩組間差異有統計學意義(t=-4.825,P=0.000)、術後5d兩組間差異無統計學意義(t=1.507,P=0.134).結論 角膜異物剔除術後使用r-bFGF有利于促進角膜上皮的脩複,恢複淚膜的穩定性.
목적 탐토중조우감성성섬유세포생장인자(r-bFGF)적안액대각막이물척제술후루막동태변화적영향.방법 림상병례치료대조연구.각막이물척제술127례(127안),수궤분위치료조(r-bFGF+양불사성치료조65례)、대조조(양불사성치료조,62례).재술전、술후3d、술후5d진행루막파렬시간(BUT)、기출루액분비시험(SIt)급각막형광소염색(FL)검사.결과 량조환자술전상술3항검사결과무차이(BUTt=0.148,P=0.883;SIt t=0.173,P=0.863;FLt=0.730,P=0.467).술후3d량조BUT、FL도유회복,치료조회복명현,량조간차이유통계학의의(BUTt=3.050,P=0.003;FLt=-6.934P=0.000),술후5d량조간BUT차이무통계학의의(t=1.407,P=0.162).술후SIt교술전축단,술후3d량조간차이유통계학의의(t=-4.825,P=0.000)、술후5d량조간차이무통계학의의(t=1.507,P=0.134).결론 각막이물척제술후사용r-bFGF유리우촉진각막상피적수복,회복루막적은정성.
Objective To investigate the efficacy of recombinant bovine basic fibroblast growth factor (r-bFGF) eye drops on tear film after corneal foreign body removal.Methods A case-control study.127 eyes of 127 patients with corneal foreign body were randomly divided into two groups:treatment group (group A,65 eyes with r-bFGF eye drops and Ofloxacin eyes drops after foreign body removal) and control group (group B,62 eyes with Ofloxacin eyes drops only).Tear film break up time (BUT),Schirmer Ⅰ test (SIt) and corneal fluorescein staining (FL) were measured preoperatively and 3 days,5 days after foreign body removal.Results On the third day after foreign body removal the BUT increased and FL reduced.The differences were both statistically significant(BUT:t =3.050,P =0.003 ; FL:t =-6.934 P =0.000,) between two groups.On the fifth day after foreign loody removal the BUT had no statistically significant difference (t =1.407,P =0.162),but the FL still had statistically significant difference (t =-3.367,P =0.001).The SIt reduced greatly after foreign body removal.The differerence were statistically significant between preoperation and on the third day after operation (t =-4.825,P =0.000),and there was no statistically significant difference between preoperation and on the fifth day (t =1.507,P =0.134) after surgery.Conclusion The r-bFGF eye drops has good effect on corneal epithlium healing and recovery of tear film stability after corneal foreign body removal.
