CAJ | 학술논문

目的：观察美他多辛联合多烯磷脂酰胆碱治疗酒精性肝病的疗效。方法70例酒精性肝病住院患者随机分为治疗组和对照组各35例，两组一般治疗相同，对照组用多烯磷脂酰胆碱针，治疗组在对照组基础上加用美他多辛片。所有患者均于治疗前、后检查血清生化指标中的丙氨酸氨基转移酶（ALT）、清天冬氨酸氨基转移酶（AST）、总胆红素（TBil）、谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、结合胆红素（DBil），并记录临床症状和体征变化，进行肝脏彩超检查，评价临床疗效。结果4周后，治疗组患者的疗效明显高于对照组。2组治疗后肝功能各项指标均较治疗前显著降低，治疗组治疗后肝功能各项指标均明显低于对照组治疗后。治疗组轻、中、重度脂肪肝的改善情况明显优于对照组。结论美他多辛和多烯磷脂酰胆碱联用疗效优于单用多烯磷脂酰胆碱。
목적：관찰미타다신연합다희린지선담감치료주정성간병적료효。방법70례주정성간병주원환자수궤분위치료조화대조조각35례，량조일반치료상동，대조조용다희린지선담감침，치료조재대조조기출상가용미타다신편。소유환자균우치료전、후검사혈청생화지표중적병안산안기전이매（ALT）、청천동안산안기전이매（AST）、총담홍소（TBil）、곡안선전태매（GGT）、감성린산매（ALP）、결합담홍소（DBil），병기록림상증상화체정변화，진행간장채초검사，평개림상료효。결과4주후，치료조환자적료효명현고우대조조。2조치료후간공능각항지표균교치료전현저강저，치료조치료후간공능각항지표균명현저우대조조치료후。치료조경、중、중도지방간적개선정황명현우우대조조。결론미타다신화다희린지선담감련용료효우우단용다희린지선담감。
Objective To explore the clinical effect of metadoxine combined with polyene phosphatidyl choline on the treatment of patients with alcoholic liver disease (ALD).Methods 70 patients with ALD were randomly divided into treatment group and control group,35 cases in each group.On the basis of conventional therapy in both groups,the control group was treated with polyene phosphatidyl choline and treatment group was treated with metadoxine tablet combined with polyene phosphatidyl choline.Serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil),glutamyltranspeptidase (GGT),alkaline phosphatase (ALP)and conjugative bilirubin (DBil)before and after treatment were observed in both groups,and changes of clinical symptoms and physical signs were recorded,color ultrasound of liver was conducted and clinical efficacy was evaluated.Results 4 weeks after treatment,clinical efficacy in treatment group was significantly higher than control group.Every index of liver function in both groups decreased significantly,and the indexes in the treatment group were significantly lower than the control group.Improvements of mild,moderate and severe fatty liver in the treatment group were signifi-cantly better than those in the control group.Conclusion Metadoxine combined with polyene phosphatidyl choline is more effective than single polyene phosphatidyl choline in treating ALD.