CAJ | 학술논문

目的：观察厄贝沙坦及倍他乐克对高血压患者动态血压的影响。方法选择80例原发性高血压患者，分成厄贝沙坦组及倍他乐克组，每组40例。治疗前及治疗后3个月行24h动态血压检测，观察血压控制情况。结果治疗前两组患者血压无显著差异，经治疗后两组患者血压都有显著性下降，两组在治疗后24h夜均舒张压没有显著差异性，其余24h收缩压、24h舒张压、日间收缩压和舒张压、夜间收缩压均有显著差异性，厄贝沙坦组血压下降更明显。结论厄贝沙坦和倍他乐克对原发性高血压降压疗效均明显，厄贝沙坦组血压下降效果更佳。
목적：관찰액패사탄급배타악극대고혈압환자동태혈압적영향。방법선택80례원발성고혈압환자，분성액패사탄조급배타악극조，매조40례。치료전급치료후3개월행24h동태혈압검측，관찰혈압공제정황。결과치료전량조환자혈압무현저차이，경치료후량조환자혈압도유현저성하강，량조재치료후24h야균서장압몰유현저차이성，기여24h수축압、24h서장압、일간수축압화서장압、야간수축압균유현저차이성，액패사탄조혈압하강경명현。결론액패사탄화배타악극대원발성고혈압강압료효균명현，액패사탄조혈압하강효과경가。
Objective To explore the influence of irbesartan and metoprolol on the ambula-tory blood pressure of patients with hypertension.Methods 80 patients with primary hypertension were selected and randomly divided into irbesartan group and metoprolol group,40 cases in each group.24 hours ambulatory blood pressure monitoring (ABPM)before treatment and 3 months af-ter treatment was conducted,and pressure control was observed in both groups.Results Before treatment,there was no significant difference of blood pressure between two groups,and blood pressure decreased significantly after treatment,and mean 24 hours diastolic blood pressure (DBP) at night after treatment did not change greatly.There were significant differences of 24 hours sys-tolic blood pressure (SBP),24 hours DBP,SBP and DBP at daytime and night,which decreased much more significantly in irbesartan group than in metoprolol group.Conclusion Irbesartan and metoprolol both have a favorable anti-hypertensive effect on primary hypertension,but irbesartan is more effective.