实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
5期
27-29
,共3页
苗伟%宋辉%李震花%张雪晶
苗偉%宋輝%李震花%張雪晶
묘위%송휘%리진화%장설정
辛伐他汀%氯吡格雷%不稳定型心绞痛%疗效%IL-6%hs-CRP
辛伐他汀%氯吡格雷%不穩定型心絞痛%療效%IL-6%hs-CRP
신벌타정%록필격뢰%불은정형심교통%료효%IL-6%hs-CRP
simvastatin%clopidogrel%unstable angina pectoris%efficacy%Interleukin-6%high-sensitivity C-reaction protein
目的:探讨辛伐他汀联合氯吡格雷治疗不稳定型心绞痛的临床疗效及对血清白介素6(IL-6)、高敏 C 反应蛋白(hs-CRP)水平的影响。方法本院2011年1月-2013年1月收治的105例不稳定型心绞痛(UAP),按照随机数字表法分为观察组53例与对照组52例,2组患者均给予常规治疗,对照组患者加用氯吡格雷片,观察组在对照组的基础上加用辛伐他汀,比较2组患者的临床疗效,IL-6、hs-CRP 水平变化,以及出院后1个月内患者的心血管事件。结果①对照组与观察组临床总有效率分别为59.6%(31/52),86.8%(46/53),2组比较差异有统计学意义(P <0.01)。②2组治疗后 IL-6、hs-CRP 水平均显著降低,差异有统计学意义(P <0.05),治疗后2组 IL-6、hs-CRP 水平比较,差异有统计学意义(P <0.05)。③2组患者随访30 d,术后心绞痛再发生、心肌梗死发生率比较,差异有统计学意义(P <0.05)。结论氯吡格雷联合辛伐他汀钙治疗不稳定型心绞痛临床效果显著,能有效改善 IL-6、hs-CRP 水平,安全性好。
目的:探討辛伐他汀聯閤氯吡格雷治療不穩定型心絞痛的臨床療效及對血清白介素6(IL-6)、高敏 C 反應蛋白(hs-CRP)水平的影響。方法本院2011年1月-2013年1月收治的105例不穩定型心絞痛(UAP),按照隨機數字錶法分為觀察組53例與對照組52例,2組患者均給予常規治療,對照組患者加用氯吡格雷片,觀察組在對照組的基礎上加用辛伐他汀,比較2組患者的臨床療效,IL-6、hs-CRP 水平變化,以及齣院後1箇月內患者的心血管事件。結果①對照組與觀察組臨床總有效率分彆為59.6%(31/52),86.8%(46/53),2組比較差異有統計學意義(P <0.01)。②2組治療後 IL-6、hs-CRP 水平均顯著降低,差異有統計學意義(P <0.05),治療後2組 IL-6、hs-CRP 水平比較,差異有統計學意義(P <0.05)。③2組患者隨訪30 d,術後心絞痛再髮生、心肌梗死髮生率比較,差異有統計學意義(P <0.05)。結論氯吡格雷聯閤辛伐他汀鈣治療不穩定型心絞痛臨床效果顯著,能有效改善 IL-6、hs-CRP 水平,安全性好。
목적:탐토신벌타정연합록필격뢰치료불은정형심교통적림상료효급대혈청백개소6(IL-6)、고민 C 반응단백(hs-CRP)수평적영향。방법본원2011년1월-2013년1월수치적105례불은정형심교통(UAP),안조수궤수자표법분위관찰조53례여대조조52례,2조환자균급여상규치료,대조조환자가용록필격뢰편,관찰조재대조조적기출상가용신벌타정,비교2조환자적림상료효,IL-6、hs-CRP 수평변화,이급출원후1개월내환자적심혈관사건。결과①대조조여관찰조림상총유효솔분별위59.6%(31/52),86.8%(46/53),2조비교차이유통계학의의(P <0.01)。②2조치료후 IL-6、hs-CRP 수평균현저강저,차이유통계학의의(P <0.05),치료후2조 IL-6、hs-CRP 수평비교,차이유통계학의의(P <0.05)。③2조환자수방30 d,술후심교통재발생、심기경사발생솔비교,차이유통계학의의(P <0.05)。결론록필격뢰연합신벌타정개치료불은정형심교통림상효과현저,능유효개선 IL-6、hs-CRP 수평,안전성호。
Objective To explore the influence of simvastatin combined with clopidogrel on prognosis and levels of IL-6 and hs-CRP CRP in patients with unstable angina pectoris (UAP). Methods 105 patients with UAP from January 2011 to January 2013 were randomly divided into observation group (n =53)and control group (n =52).On the basis of conventional treatment, control group was treated with clopidogrel,while observation group was treated with simvastatin plus clopidogrel.Clinical efficacy,levels of IL-6 and hs-CRP and cardiovascular events were com-pared between two groups.Results The total effective rate was 59.6% in the control group, which was significantly lower than 86.8% in the observation group (P <0.01).After treatment, levels of IL-6 and hs-CRP decreased significantly in both groups (P <0.05),and there were signifi-cant differences between two groups (P <0.05).All the patients were followed up for 30 days,and there were significant differences in aspect of incidence of postoperative angina and myocardial in-farction between two groups (P <0.05).Conclusion Calcium clopidogrel combined with simvas-tatin can effectively improve levels of IL-6 and hs-CRP in the treatment of patients with UAP.