CAJ | 학술논문

目的：探讨肠外营养支持治疗对围化疗期晚期胃肠道肿瘤患者营养状况及免疫功能的影响。方法将90例晚期胃肠道肿瘤患者随机分为对照组和观察组，通过检测2组患者化疗前后的各项营养指标和免疫指标的变化，对2种治疗效果进行对比研究。结果观察组患者化疗前和第1、2疗程后与对照组比各项营养指标和免疫功能指标均无明显变化；第3疗程后各项营养指标和免疫功能指标较对照组均有明显改善，观察组白细胞减少、血小板减少、恶心呕吐、腹泻发生率显著低于对照组；耐受性更好。结论肠外营养支持治疗可改善晚期胃肠道肿瘤化疗患者的营养状况及免疫功能，减轻化疗不良反应，保证围化疗期安全有重要意义。
목적：탐토장외영양지지치료대위화료기만기위장도종류환자영양상황급면역공능적영향。방법장90례만기위장도종류환자수궤분위대조조화관찰조，통과검측2조환자화료전후적각항영양지표화면역지표적변화，대2충치료효과진행대비연구。결과관찰조환자화료전화제1、2료정후여대조조비각항영양지표화면역공능지표균무명현변화；제3료정후각항영양지표화면역공능지표교대조조균유명현개선，관찰조백세포감소、혈소판감소、악심구토、복사발생솔현저저우대조조；내수성경호。결론장외영양지지치료가개선만기위장도종류화료환자적영양상황급면역공능，감경화료불량반응，보증위화료기안전유중요의의。
Objective To explore the influence of parenteral nutrition (PN)supportive therapy on the nutritional status and immune function in patients with advanced gastrointestinal tu-mor in peri-chemotherapy period.Methods 90 patients with advanced gastrointestinal tumor were randomly divided into control group and observation group.Efficacy was compared between two groups by detecting the changes of various nutritional and immune indexes before and after chemotherapy.Results There were no significant differences of the nutritional and immune func-tion indexes between two groups before chemotherapy and after the first-second cycle of chemothera-py.All nutritional and immune function indexes after the third cycle of chemotherapy in the obser-vation group were significantly better than those in the control group.The incidence rate of compli-cations such as leucopenia,thrombocytopenia,nausea,vomiting and diarrhea in the observation group was significantly lower than the control group.Conclusion PN supportive therapy can not only ameliorate the nutritional status and immune function of patients with advanced gastrointestinal tumor,but also alleviate the chemotherapy-induced adverse reactions,so it is very important for safety in peri-chemotherapy period.