CAJ | 학술논문

目的：探讨血清甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TMAb）、甲状腺过氧化物酶抗体（TPOAb）对自身免疫性甲状腺疾病（AITD）的诊断价值。方法100例甲状腺功能异常患者根据血清中三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）水平分为甲亢组和甲减组，每组50例；另选择50例甲状腺功能正常人群作为对照组。各组患者均采集静脉血5 mL，分离血清，放射免疫法测定患者血清中 TGAb、TMAb、TPOAb、T3、T4、TSH 水平。观察各组患者血清中TGAb、TMAb、TPOAb 阳性率；比较各组 TGAb、TMAb、TPOAb 阳性患者血清水平。结果甲亢组和甲减组血清 TPOAb 阳性率均明显高于血清 TGAb、TMAb 阳性率；甲亢组、甲减组患者血清 TGAb、TMAb、TPOAb 阳性率均明显高于对照组；甲减组患者血清 TGAb、TMAb、TPOAb 阳性率均明显高于甲亢组。甲亢组和甲减组患者血清 TGAb、TMAb、TPOAb 水平均明显高于对照组。甲减组患者血清中 TGAb、TMAb、TPOAb 水平均明显高于甲亢组。结论 TPOAb 在 AITD 的诊断中具有重要意义，为AITD 的诊断、治疗及预后评估提供了重要依据。
목적：탐토혈청갑상선구단백항체（TGAb）、갑상선미립체항체（TMAb）、갑상선과양화물매항체（TPOAb）대자신면역성갑상선질병（AITD）적진단개치。방법100례갑상선공능이상환자근거혈청중삼전갑상선원안산（T3）、갑상선소（T4）、촉갑상선격소（TSH）수평분위갑항조화갑감조，매조50례；령선택50례갑상선공능정상인군작위대조조。각조환자균채집정맥혈5 mL，분리혈청，방사면역법측정환자혈청중 TGAb、TMAb、TPOAb、T3、T4、TSH 수평。관찰각조환자혈청중TGAb、TMAb、TPOAb 양성솔；비교각조 TGAb、TMAb、TPOAb 양성환자혈청수평。결과갑항조화갑감조혈청 TPOAb 양성솔균명현고우혈청 TGAb、TMAb 양성솔；갑항조、갑감조환자혈청 TGAb、TMAb、TPOAb 양성솔균명현고우대조조；갑감조환자혈청 TGAb、TMAb、TPOAb 양성솔균명현고우갑항조。갑항조화갑감조환자혈청 TGAb、TMAb、TPOAb 수평균명현고우대조조。갑감조환자혈청중 TGAb、TMAb、TPOAb 수평균명현고우갑항조。결론 TPOAb 재 AITD 적진단중구유중요의의，위AITD 적진단、치료급예후평고제공료중요의거。
Objective To explore the diagnostic value of serum thyroglobulin antibody (TGAb),thyroid microsomal antibody (TMAb)and thyroid peroxidase antibody (TPOAb)in au-toimmune thyroid disease (AITD).Methods 100 patients with thyroid dysfunction were divided into hyperthyroidism group and hypothyroidism group according to the levels of serum triiodothy-ronine (T3),thyroxine (T4)and thyroid stimulating hormone (TSH),50 cases in each group.An-other 50 patients with normal thyroid function were collected and designed as control group.5 mL venous blood was collected,and the serum was separated.The levels of TGAb,TMAb,TPOAb, T3,T4 and TSH were detected by radioimmunoassay in each group,positive rates of TGAb,TMAb and TPOAb were observed,and the serum levels of positive TGAb,TMAb and TPOAb were com-pared among all the groups.Results The positive rate of serum TPOAb was significantly higher than those of TGAb and TMAb in hyperthyroidism group and hypothyroidism group.The positive rates of serum TGAb,TMAb and TPOAb in hyperthyroidism and hypothyroidism groups were sig-nificantly higher than the control group,and those in hypothyroidism group were higher than hy-perthyroidism group.The levels of serum TGAb,TMAb and TPOAb in hyperthyroidism group and hypothyroidism group were significantly higher than the control group,and those in hypothyroidism group were obviously higher than hyperthyroidism group.Conclusion TPOAb shows an important significance in diagnosing AITD,which provides an important evidence for AITD diagnosis, treatment and prognosis.