CAJ | 학술논문

目的：了解儿童重组乙肝疫苗基础免疫与加强免疫后的免疫持久性。方法选择免疫史信息保存完备、婴儿期完成0-1-6月基础免疫的493名中小学生为对象。对所有对象检测抗-HBs等指标，并对是否作加强免疫、不同年龄时间作加强免疫以及距末次免疫接种不同时间的抗-HBs平均水平和达到乙肝免疫保护水平的阳性率作比较，分析乙肝疫苗不同免疫接种情况下的免疫持久性。结果加强免疫组与基础免疫组抗-HBs阳性率分别为91.40%和57.14%，两组比较差异有统计学意义（ P<0.01）。10μg加强免疫组0~5年后抗-HBs滴度较高，抗体阳性率94.99%；5μg加强免疫组8~15年后抗-HBs滴度较低，抗体阳性率下降至64.71%，与基础免疫组比较差异无统计学意义（ P=0.49）。结论乙肝疫苗加强免疫后可提高抗-HBs阳性率，远期抗-HBs滴度水平和抗体阳性率降低；婴儿期基础免疫3~11年后免疫记忆缺失率低。
목적：료해인동중조을간역묘기출면역여가강면역후적면역지구성。방법선택면역사신식보존완비、영인기완성0-1-6월기출면역적493명중소학생위대상。대소유대상검측항-HBs등지표，병대시부작가강면역、불동년령시간작가강면역이급거말차면역접충불동시간적항-HBs평균수평화체도을간면역보호수평적양성솔작비교，분석을간역묘불동면역접충정황하적면역지구성。결과가강면역조여기출면역조항-HBs양성솔분별위91.40%화57.14%，량조비교차이유통계학의의（ P<0.01）。10μg가강면역조0~5년후항-HBs적도교고，항체양성솔94.99%；5μg가강면역조8~15년후항-HBs적도교저，항체양성솔하강지64.71%，여기출면역조비교차이무통계학의의（ P=0.49）。결론을간역묘가강면역후가제고항-HBs양성솔，원기항-HBs적도수평화항체양성솔강저；영인기기출면역3~11년후면역기억결실솔저。
Objective To observe long-term efficacy of recombinant hepatitis B vaccines for children received fundamental immunization or booster dose. Methods 493 school students from Deqing county with complete information of immunization history were investigated and their serological markers were detected. 430 students received booster dose vaccines at 3-11 years old and were defined as booster group while the remaining 63 students were defined as fundamental group. Results All vaccines the 493 students received for fundamental immunization were recombinant. Compared with fundamental group(57. 14%),booster group had significantly higher Anti-HBs positive rate of 91. 40%(P<0. 01). And the Anti-HBs positive rate had a high level of 94. 99% when 0-5 years after booster immunization while it declined to 64. 71% after 8-15 years and showed no significant difference compared with fundamental group. Conclusion Anti-HBs level and anti -HBs positive rate can significantly increase for short periods after booster immunization,and may decline considerably for long-term. Immunologic amnesia rate is low when 3 -11 years after fundamental immunization among infants.