CAJ | 학술논문

目的：了解血清Ⅳ型胶原(Ⅳ-C)的含量水平在肝纤维化患者中的变化，分析Ⅳ-C对肝纤维化程度的诊断价值。方法采用放射免疫法测定110例各种病毒性肝炎患者及100例健康献血者血清Ⅳ-C水平，比较各组病毒性肝炎之间及健康献血者血清Ⅳ-C水平差异，结合病理结果进行分析。结果血清Ⅳ-C水平在肝炎患者中明显升高，以肝硬化者为最高，慢性肝炎患者与健康对照组及急性黄疸性肝炎组比较，差异有高度统计学意义(P＜0.01)，其升高程度与肝纤维化及肝病严重程度呈正相关。结论动态测定血清Ⅳ-C水平，可作为反映慢性肝病肝纤维化严重程度和预后的指标。
목적：료해혈청Ⅳ형효원(Ⅳ-C)적함량수평재간섬유화환자중적변화，분석Ⅳ-C대간섬유화정도적진단개치。방법채용방사면역법측정110례각충병독성간염환자급100례건강헌혈자혈청Ⅳ-C수평，비교각조병독성간염지간급건강헌혈자혈청Ⅳ-C수평차이，결합병리결과진행분석。결과혈청Ⅳ-C수평재간염환자중명현승고，이간경화자위최고，만성간염환자여건강대조조급급성황달성간염조비교，차이유고도통계학의의(P＜0.01)，기승고정도여간섬유화급간병엄중정도정정상관。결론동태측정혈청Ⅳ-C수평，가작위반영만성간병간섬유화엄중정도화예후적지표。
Objective To investigate the change of serum IV-C content in patients with hepatic fibrosis so so to analyze the diagnostic value of IV-C for hepatic fibrosis degree.Methods R adioim m unoassay was adopted to measure the level of serum IV-C in 110 patients with virus hepatitis and 100 healthy people,and the differences of serum IV-C in several chronic hepatitis and in healthy blood donors were com-pared and analyzed in com bination with pathological results.Results The level of serum IV-C in patients with chronic hepatitis obviously heightened ,with the highest of liver cirrhosis.The differences betw een chronic hepatitis sufferers and the healthy control group and acute icterohepatitis sufferers were of high statistical significance (P<0 .01 ).The increased degree of serum IV-C was positively related to the de-gree of hepatic fibrosis and severity of liver disease.Conclusion Dynam ic measurem ent of serum IV-C level can reflect the order of severity of hepatic fibrosis in chronic liver disease and its prognostic indicators.