医药导报
醫藥導報
의약도보
HERALD OF MEDICINE
2014年
6期
721-722
,共2页
杨增艳%周海松%赵湘培%唐瑾%柏春晖
楊增豔%週海鬆%趙湘培%唐瑾%柏春暉
양증염%주해송%조상배%당근%백춘휘
牛大力水提物%牛大力醇提物%毒性实验,急性%最大耐受量
牛大力水提物%牛大力醇提物%毒性實驗,急性%最大耐受量
우대력수제물%우대력순제물%독성실험,급성%최대내수량
Water extract of Radix millettiae speciosae%Ethanol extract of Radix millettiae speciosae%Toxicity experiment,acute%Maximum tolerated dose
目的：对牛大力水提取物和醇提取物的急性毒性进行初步研究。方法通过测定小鼠的最大耐受量（MTD）评价牛大力的安全性。结果牛大力水提取物的MTD﹥1000 g·kg-1，相当于人拟用日剂量的110倍；牛大力醇提物的MTD﹥1700 g·kg-1，相当于人拟用日剂量的186倍。结论牛大力无明显毒性，常用日剂量安全。
目的：對牛大力水提取物和醇提取物的急性毒性進行初步研究。方法通過測定小鼠的最大耐受量（MTD）評價牛大力的安全性。結果牛大力水提取物的MTD﹥1000 g·kg-1，相噹于人擬用日劑量的110倍；牛大力醇提物的MTD﹥1700 g·kg-1，相噹于人擬用日劑量的186倍。結論牛大力無明顯毒性，常用日劑量安全。
목적：대우대력수제취물화순제취물적급성독성진행초보연구。방법통과측정소서적최대내수량（MTD）평개우대력적안전성。결과우대력수제취물적MTD﹥1000 g·kg-1，상당우인의용일제량적110배；우대력순제물적MTD﹥1700 g·kg-1，상당우인의용일제량적186배。결론우대력무명현독성，상용일제량안전。
Methods The maximum tolerated dose( MTD)of water and ethanol extracts of Radix millettiae speciosae were measured for the safety evaluation. Results Maximal tolerated dose( MTD)of water extract was higher than 1 000 g·kg-1 ,which equaled to 110 times the dose for human adults(60 kg). MTD of ethanol extract was higher than 1 700 g·kg-1 ,which equaled to 186 times the dose for human adults(60 kg). Conclusion Radix millettiae speciosae does not have obvious toxicity,thus its routine clinical dose is safe and feasible.
