CAJ | 학술논문

白内障术后晶状体后囊膜混浊(posterior capsular opacification,PCO)(后发性白内障)是现代白内障术后最常见的并发症,防治PCO是保障白内障手术远期疗效的关键.术中残留的晶状体上皮细胞增生、移行和上皮-间质转化是PCO形成的细胞学基础.转化生长因子β(transforminggrowth factor beta,TGF-β)通过正性调控晶状体上皮细胞的增生、迁移、转分化及凋亡等,促进了PCO的发生发展过程.设想可通过对TGF-β、TGF-β受体及其下游通路中的Smad蛋白和基质金属蛋白酶等进行干预来防治PCO.采用结膜囊涂抹及前房注射TGF-β抗体、基质金属蛋白酶抑制剂及结缔组织生长因子反义寡核苷酸或特异性抗体等将成为PCO防治的新途径.
백내장술후정상체후낭막혼탁(posterior capsular opacification,PCO)(후발성백내장)시현대백내장술후최상견적병발증,방치PCO시보장백내장수술원기료효적관건.술중잔류적정상체상피세포증생、이행화상피-간질전화시PCO형성적세포학기출.전화생장인자β(transforminggrowth factor beta,TGF-β)통과정성조공정상체상피세포적증생、천이、전분화급조망등,촉진료PCO적발생발전과정.설상가통과대TGF-β、TGF-β수체급기하유통로중적Smad단백화기질금속단백매등진행간예래방치PCO.채용결막낭도말급전방주사TGF-β항체、기질금속단백매억제제급결체조직생장인자반의과핵감산혹특이성항체등장성위PCO방치적신도경.
Posterior capsular opacification (PCO) is a most common complication of modem cataract surgery.The prevention of PCO is the key to ensure long-term efficacy of cataract surgery.The proliferation,migration,and epithelial-mesenchymal transition of intraoperative residual lens epithelial cells are cellular basis of PCO.Transforming growth factor β,(TGF-β) participates in the development of PCO by regulating lens epithelial cells proliferation,migration,differentiation and apoptosis.It is envisaged that the regulation of TGF-β,TGF-β receptor and its downstream pathway (Smad proteins and matrix metalloproteinases) can prevent PCO.By the means of conjunctival sac daub and anterior chamber injection,TGF-β antibodies,matrix metalloproteinase inhibitors and connective tissue growth factor antisense oligonucleotides or specific antibodies may become the new ways of preventing PCO.