CAJ | 학술논문

目的：观察吸入噻托溴铵联合沙美特罗替卡松对慢性阻塞性肺疾病急性加重期（ AECOPD）的临床疗效。方法将2010年1月~2013年1月入院的62例AECOPD患者随机分为实验组和对照组，实验组31例给予噻托溴铵联合沙美特罗替卡松治疗，对照组31例仅给予沙美特罗替卡松治疗。治疗前及治疗结束出院时分别检测两组的肺功能指标（ FEV1、FVC、FEV1/FVC）、血气分析（PO2、SaO2、PCO2）、6 min步行实验（6MWT），并记录住院时间，进行对比分析。结果两组经过治疗后均有明显疗效，未见明显不良反应；实验组在肺功能指标、血气分析、6MWT及住院时间方面均优于对照组（ P﹤0.05）。结论噻托溴铵联合沙美特罗替卡松治疗AECOPD疗效确切，具有较高临床应用价值。
목적：관찰흡입새탁추안연합사미특라체잡송대만성조새성폐질병급성가중기（ AECOPD）적림상료효。방법장2010년1월~2013년1월입원적62례AECOPD환자수궤분위실험조화대조조，실험조31례급여새탁추안연합사미특라체잡송치료，대조조31례부급여사미특라체잡송치료。치료전급치료결속출원시분별검측량조적폐공능지표（ FEV1、FVC、FEV1/FVC）、혈기분석（PO2、SaO2、PCO2）、6 min보행실험（6MWT），병기록주원시간，진행대비분석。결과량조경과치료후균유명현료효，미견명현불량반응；실험조재폐공능지표、혈기분석、6MWT급주원시간방면균우우대조조（ P﹤0.05）。결론새탁추안연합사미특라체잡송치료AECOPD료효학절，구유교고림상응용개치。
Objective To explore the clinical curative effect of tiotropium bromide combined with salmeterol fluticasone propionate on patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods 62 cases with AECOPD hospitalized from Jan. ,2010 to Jan. ,2013 were randomly divided into 2 groups:experiment group and control group,31 in each;salmeterol fluticasone propionate was applied to all the patients in the 2 groups,while tiotropium bromide was added to patients in experiment group;the pulmonary functions( FEV1、FVC、FEV1/FVC),blood gas( PO2、SaO2、PCO2 )were detected and 6-minute walk test(6-MWT)was performed before and after treatment,respectively,and the days of hospitalization were recorded;a contrast study was then made. Results The treatment in the 2 groups was effective and no obvious side effect occurred;experiment group was superior to control group in pulmonary function,blood gas,6-MWT and the days of hospitalization(P﹤0. 05). Conclusions The treatment of tiotropium bromide combined with salmeterol fluticasone propionate is of definite curative effect on patients with AECOPD and is worthy of wider clinical application.