检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
6期
622-627
,共6页
刘华%郑沁%曾婷婷%叶远馨%李贵星%粟军
劉華%鄭沁%曾婷婷%葉遠馨%李貴星%粟軍
류화%정심%증정정%협원형%리귀성%속군
乳酸脱氢酶%急性白血病%诊断%疾病进程%疗效评估
乳痠脫氫酶%急性白血病%診斷%疾病進程%療效評估
유산탈경매%급성백혈병%진단%질병진정%료효평고
Lactate dehydrogenase%Acute leukemia%Diagnosis%Disease progression%Therapeutic effect evaluation
目的:通过动态监测急性白血病(AL)患者血清乳酸脱氢酶(LDH)水平,探讨LDH对AL患者病情监测和预后评估的临床意义。方法回顾分析初诊的1184例AL患者的2170例次LDH水平,评估患者LDH水平随疾病进程的变化趋势并探究其与AL的预后和疾病进展的关系,同时分析LDH与血细胞、骨髓白血病细胞比例、白血病融合基因和流式细胞术分型等相关辅助诊断指标的关系。结果 AL患者不同病程阶段的LDH水发平不同,其中初发组及复发组LDH水平明显高于缓解组及正常对照组(P<0.05)。缓解组LDH水平有所减低,但仍高于正常对照组(P<0.05)。急性淋巴细胞白血病(ALL)组 LDH 水平明显高于急性髓性白血病(AML)组(P<0.05)。与其他AL诊断及预后相关指标比较,LDH与骨髓白血病细胞百分数、白血病相关融合基因、细胞免疫分型等都有相关性(P<0.05)。结论不同病程阶段、不同亚型AL患者的血清LDH水平有差异,血清LDH水平可作为AL诊断、疾病进程及疗效评估的辅助指标。
目的:通過動態鑑測急性白血病(AL)患者血清乳痠脫氫酶(LDH)水平,探討LDH對AL患者病情鑑測和預後評估的臨床意義。方法迴顧分析初診的1184例AL患者的2170例次LDH水平,評估患者LDH水平隨疾病進程的變化趨勢併探究其與AL的預後和疾病進展的關繫,同時分析LDH與血細胞、骨髓白血病細胞比例、白血病融閤基因和流式細胞術分型等相關輔助診斷指標的關繫。結果 AL患者不同病程階段的LDH水髮平不同,其中初髮組及複髮組LDH水平明顯高于緩解組及正常對照組(P<0.05)。緩解組LDH水平有所減低,但仍高于正常對照組(P<0.05)。急性淋巴細胞白血病(ALL)組 LDH 水平明顯高于急性髓性白血病(AML)組(P<0.05)。與其他AL診斷及預後相關指標比較,LDH與骨髓白血病細胞百分數、白血病相關融閤基因、細胞免疫分型等都有相關性(P<0.05)。結論不同病程階段、不同亞型AL患者的血清LDH水平有差異,血清LDH水平可作為AL診斷、疾病進程及療效評估的輔助指標。
목적:통과동태감측급성백혈병(AL)환자혈청유산탈경매(LDH)수평,탐토LDH대AL환자병정감측화예후평고적림상의의。방법회고분석초진적1184례AL환자적2170례차LDH수평,평고환자LDH수평수질병진정적변화추세병탐구기여AL적예후화질병진전적관계,동시분석LDH여혈세포、골수백혈병세포비례、백혈병융합기인화류식세포술분형등상관보조진단지표적관계。결과 AL환자불동병정계단적LDH수발평불동,기중초발조급복발조LDH수평명현고우완해조급정상대조조(P<0.05)。완해조LDH수평유소감저,단잉고우정상대조조(P<0.05)。급성림파세포백혈병(ALL)조 LDH 수평명현고우급성수성백혈병(AML)조(P<0.05)。여기타AL진단급예후상관지표비교,LDH여골수백혈병세포백분수、백혈병상관융합기인、세포면역분형등도유상관성(P<0.05)。결론불동병정계단、불동아형AL환자적혈청LDH수평유차이,혈청LDH수평가작위AL진단、질병진정급료효평고적보조지표。
Objective To monitor dynamically serum lactate dehydrogenase (LDH)levels in acute leukemia (AL)patients,and to investigate the clinical significance on the monitoring of pathogenetic condition and prognosis evaluation.Methods The LDH levels of 2 1 70 times from 1 1 84 de novo AL patients were analyzed retrospectively. The relationship of LDH levels with disease progression and AL prognosis was evaluated.The relationships between LDH levels and blood cell counts,the proportion of bone marrow leukemia cells,cytogenetic abnormality,flow cytometry immunophenotyping and the other related diagnostic markers were analyzed.Results LDH levels of AL patients in different stages of the disease were different.The LDH levels of incipient and relapse stages in AL patients were significantly higher than those of remission stage in AL patients and those in healthy controls (P<0.05 ).The LDH levels of remission stage in AL patients reduced,but were still significantly higher than those in healthy controls (P<0.05).The LDH levels of acute lymphoblastic leukemia (ALL)patients were significantly higher than those of acute myeloid leukemia (AML)patients (P<0.05 ).Compared with the other diagnostic and prognostic indicators of AL, LDH levels had correlation with the proportion of bone marrow leukemia cells,cytogenetic abnormality and flow cytometry immunophenotyping (P<0.05).Conclusions The serum LDH levels of AL patients in different stages and different subtypes are different significantly.The LDH levels can be used as a supplementary indicator of AL diagnosis,disease progression and therapeutic effect evaluation.