检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
6期
613-616
,共4页
低相对分子质量肝素%血栓弹力图%抗Xa活性
低相對分子質量肝素%血栓彈力圖%抗Xa活性
저상대분자질량간소%혈전탄력도%항Xa활성
Low molecular weight heparin%Thromboelastography%Anti-Xa activity
目的：尝试使用血栓弹力图（TEG）R时间来监测低相对分子质量肝素（LMWH）的临床用药。方法选取本院肾脏内科肾病综合症住院患者20例，患者首次用药和第二次用药后4 h均抽血进行TEG和抗Xa活性检测：TEG R时间及抗Xa活性的检测；TEG R时间与抗Xa活性的相关性分析；抗Xa活性与首次用药间的相关性分析；TEG R时间与首次用药的相关性分析；不同剂量用药间抗Xa活性的比较分析；不同剂量用药间TEG R时间的比较分析。结果 TEG R时间与抗Xa活性无相关性（P＝0．54，R＝-0．1449）；抗Xa活性与首次用药量无相关性（P＝0．26，R＝-0．2636）；TEG R时间与首次用药量间有显著相关性（P＜0．0001，R＝0．875）；2次用药间抗Xa活性存在差异（P＝0．0005，t ＝4．152）；2次用药间 TEG R时间存在显著差异（P＜0．0001，t ＝15．19）。结论 TEG R时间比抗Xa活性更能准确反映出患者的LMWH用药情况。
目的：嘗試使用血栓彈力圖（TEG）R時間來鑑測低相對分子質量肝素（LMWH）的臨床用藥。方法選取本院腎髒內科腎病綜閤癥住院患者20例，患者首次用藥和第二次用藥後4 h均抽血進行TEG和抗Xa活性檢測：TEG R時間及抗Xa活性的檢測；TEG R時間與抗Xa活性的相關性分析；抗Xa活性與首次用藥間的相關性分析；TEG R時間與首次用藥的相關性分析；不同劑量用藥間抗Xa活性的比較分析；不同劑量用藥間TEG R時間的比較分析。結果 TEG R時間與抗Xa活性無相關性（P＝0．54，R＝-0．1449）；抗Xa活性與首次用藥量無相關性（P＝0．26，R＝-0．2636）；TEG R時間與首次用藥量間有顯著相關性（P＜0．0001，R＝0．875）；2次用藥間抗Xa活性存在差異（P＝0．0005，t ＝4．152）；2次用藥間 TEG R時間存在顯著差異（P＜0．0001，t ＝15．19）。結論 TEG R時間比抗Xa活性更能準確反映齣患者的LMWH用藥情況。
목적：상시사용혈전탄력도（TEG）R시간래감측저상대분자질량간소（LMWH）적림상용약。방법선취본원신장내과신병종합증주원환자20례，환자수차용약화제이차용약후4 h균추혈진행TEG화항Xa활성검측：TEG R시간급항Xa활성적검측；TEG R시간여항Xa활성적상관성분석；항Xa활성여수차용약간적상관성분석；TEG R시간여수차용약적상관성분석；불동제량용약간항Xa활성적비교분석；불동제량용약간TEG R시간적비교분석。결과 TEG R시간여항Xa활성무상관성（P＝0．54，R＝-0．1449）；항Xa활성여수차용약량무상관성（P＝0．26，R＝-0．2636）；TEG R시간여수차용약량간유현저상관성（P＜0．0001，R＝0．875）；2차용약간항Xa활성존재차이（P＝0．0005，t ＝4．152）；2차용약간 TEG R시간존재현저차이（P＜0．0001，t ＝15．19）。결론 TEG R시간비항Xa활성경능준학반영출환자적LMWH용약정황。
Objective To attempt to use thromboelastography (TEG)reaction time (R)to monitor the clinical use of low molecular weight heparin (LMWH).Methods A total of 20 hospitalized patients from nephrology department with nephritic syndrome were enrolled.Blood samples were collected at 4 h after both firstly and secondly receiving dose in order to perform TEG and anti-Xa activity test.TEG R and anti-Xa activity were determined.The associations between TEG R and anti-Xa activity,between the dose of taking drugs at first time and anti-Xa activity,and between the dose of taking drugs at first time and TEG R,were analyzd.The comparative analysis of anti-Xa activity with different doses of taking drugs was performed.The comparative analysis of TEG R with different doses of taking drugs was performed.Results There was no association between TEG R and anti-Xa activity (P=0.54,R=-0.1 44 9).There was no association between anti-Xa activity and the dose of taking drugs at first time (P=0.26,R=-0.263 6).There was obvious association between TEG R and the dose of taking drugs at first time (P<0.000 1 ,R=0.875).There was difference in anti-Xa activity between the 2 doses of taking drugs (P=0.000 5,t =4.152).There was significant difference in TEG R between the 2 doses of taking drugs (P<0.000 1,t=15.19).Conclusions TEG R reflects patients′condition of using LMWH much more accurately than anti-Xa activity.
