临床医学
臨床醫學
림상의학
CLINICAL MEDICINE
2014年
6期
15-16
,共2页
对比剂肾病%碘对比剂%静脉泌尿系造影%CT 增强扫描%中性粒细胞明胶酶相关脂质运载蛋白
對比劑腎病%碘對比劑%靜脈泌尿繫造影%CT 增彊掃描%中性粒細胞明膠酶相關脂質運載蛋白
대비제신병%전대비제%정맥비뇨계조영%CT 증강소묘%중성립세포명효매상관지질운재단백
Contrast medium nephropathy%Iodine contrast agent%Venous urinary imaging%CT enhanced scan%Neutrophil gelatinase-associated lipocalin(NGAL)
目的:观察肾功能正常患者作碘对比剂静脉泌尿系造影和 CT 增强扫描后尿液中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)的变化。方法选择127例肾功能正常作碘对比剂静脉泌尿系造影和 CT 增强扫描的患者,检测其碘对比剂推注前血浆肌酐(Scr)和尿液 NGAL 水平,碘对比剂推注后4 h、12 h、24 h 尿液 NGAL 及12 h、24 h、48 h、72 h 的 Scr 水平。结果1例患者诊断为对比剂肾病(CIN),其尿液 NGAL 在碘对比剂推注后4 h 明显升高,比 Scr 升高早48 h 以上。结论 NGAL 是 CIN 早期、敏感的诊断指标。
目的:觀察腎功能正常患者作碘對比劑靜脈泌尿繫造影和 CT 增彊掃描後尿液中性粒細胞明膠酶相關脂質運載蛋白(neutrophil gelatinase-associated lipocalin,NGAL)的變化。方法選擇127例腎功能正常作碘對比劑靜脈泌尿繫造影和 CT 增彊掃描的患者,檢測其碘對比劑推註前血漿肌酐(Scr)和尿液 NGAL 水平,碘對比劑推註後4 h、12 h、24 h 尿液 NGAL 及12 h、24 h、48 h、72 h 的 Scr 水平。結果1例患者診斷為對比劑腎病(CIN),其尿液 NGAL 在碘對比劑推註後4 h 明顯升高,比 Scr 升高早48 h 以上。結論 NGAL 是 CIN 早期、敏感的診斷指標。
목적:관찰신공능정상환자작전대비제정맥비뇨계조영화 CT 증강소묘후뇨액중성립세포명효매상관지질운재단백(neutrophil gelatinase-associated lipocalin,NGAL)적변화。방법선택127례신공능정상작전대비제정맥비뇨계조영화 CT 증강소묘적환자,검측기전대비제추주전혈장기항(Scr)화뇨액 NGAL 수평,전대비제추주후4 h、12 h、24 h 뇨액 NGAL 급12 h、24 h、48 h、72 h 적 Scr 수평。결과1례환자진단위대비제신병(CIN),기뇨액 NGAL 재전대비제추주후4 h 명현승고,비 Scr 승고조48 h 이상。결론 NGAL 시 CIN 조기、민감적진단지표。
Objective To observe the changes of urine neutrophil gelatinase-associated lipocalin(NGAL)in patients with normal renal function after urinary iodine contrast agent vein angiography and CT enhanced scan. Methods One hundred and twenty-seven patients with normal renal function underwent urinary iodine contrast agent vein angiography and CT enhanced scan were selected. The serum creatinine(Scr)and urine NGAL levels before iodine contrast agent injection,and the urine NGAL levels at 4 h,12 h,24 h after iodine contrast agent injection,the Scr levels at 12 h,24 h,48 h,72 h after iodine contrast agent injection were detected. Results One case was diagnosed as contrast medium nephropathy(CIN),the urine NGAL level was elevated obviously at 4 hours after iodine contrast agent injection, which is 48 h earlier than the elevation of Scr. Conclusion NGAL is an early and sensitive diagnosis indicators of CIN.