6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯的合成和抗球虫活性研究
6-완양기-7-갑기-4-간기-3-규람최산을지적합성화항구충활성연구
Synthesis and anticoccidial activities of ethyl 6-alkoxyl-4-hydroxy-7-methyl-3-quinolone-carboxylates
  • 万方数据
    化学研究与应用 화학연구여응용
    CHEMICAL RESEARCH AND APPLICATION
    2014年 6期 900-904 ,共5页

    陈广民%徐箭%翁亚彪%王玉良

    진엄민%서전%옹아표%왕옥량

    6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯%抗球虫活性%ACI方法 6-烷氧基-7-甲基-4-羥基-3-喹啉羧痠乙酯%抗毬蟲活性%ACI方法
    6-완양기-7-갑기-4-간기-3-규람최산을지%항구충활성%ACI방법
    ethyl 6-alkoxyl-4-hydroxy-7-methyl-3-quinoline-carboxylates%anticoccidial activity%ACI method
    本文设计和合成了4个新的6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯类化合物,新化合物的结构经1H NMR,IR,HR-MS所证实。依据ACI方法(抗球虫指数)对其进行了抗球虫活性试验,结果表明：化合物5a、5d在27mg·kg-1时对于柔嫩艾美耳球虫具有一定的抗球虫活性。
    본문설계화합성료4개신적6-완양기-7-갑기-4-간기-3-규람최산을지류화합물,신화합물적결구경1H NMR,IR,HR-MS소증실。의거ACI방법(항구충지수)대기진행료항구충활성시험,결과표명：화합물5a、5d재27mg·kg-1시대우유눈애미이구충구유일정적항구충활성。
    Four new compounds,6-alkoxyl-4-hydroxy-7-methyl-3-quinoline-carboxylates,were synthesized. Their structures were i-dentified by 1 HNMR,HR-MS,and IR spectra. The anticoccidial activity of new compounds were tested according to the ACI( the an-ticoccidial index)method. The results showed that compounds 5a and 5d exhibited good anticoccidial activity against Eimeria tenella in the chicken diet with a dose of 27 mg·Kg-1 .
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