CAJ | 학술논문

以取代苯酚和氯乙酸为原料，合成取代苯氧乙酸，然后经过酰氯化，酯化得到取代苯氧乙酰基异硫氰酸酯，再和2-氨基-4-苯基噻唑反应得到4种N-(取代苯氧乙酰基)-N′-(4-苯基噻唑-2-基)硫脲类化合物，其中3种化合物为首次报道。化合物结构经1 H NMR、IR和元素分析得到确证。初步室内生测结果表明该类化合物具有一定的抑菌活性。
이취대분분화록을산위원료，합성취대분양을산，연후경과선록화，지화득도취대분양을선기이류청산지，재화2-안기-4-분기새서반응득도4충N-(취대분양을선기)-N′-(4-분기새서-2-기)류뇨류화합물，기중3충화합물위수차보도。화합물결구경1 H NMR、IR화원소분석득도학증。초보실내생측결과표명해류화합물구유일정적억균활성。
In this paper,Four N-(substituted phenoxyacetyl)-N′-(4-phenyl thiazol-2-yl)thiourea were synthesized by reaction of 2-amino-4-phenylthiazole and substituted phenoxyacetyl isothiocyanates which was prepared by acyl chlorination and esterification of substituted phenoxyacetic acids that were obtained by using chloroacetic acid and substituted phenols as reactant. Three of them were new compounds. Their structures had been determined by 1 H NMR,IR and elemental analysis. The preliminary biological ac-tivities had been tested,and the results showed that most of them exhibited fungus-inhibiting.