化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2014年
6期
877-880
,共4页
吡啶甲酸%吡啶甲醛%乙烯基吡啶%吡啶乙醇%药物中间体
吡啶甲痠%吡啶甲醛%乙烯基吡啶%吡啶乙醇%藥物中間體
필정갑산%필정갑철%을희기필정%필정을순%약물중간체
pyridine carboxylic acid%pyridine carboxaldehyde%vinyl pyridine%pyridine ethanol%pharmaceutical intermediate
2-氨基-2-(2-甲氧基-5-吡啶)乙醇是一种重要的药物中间体。本论文提供一种以2-甲氧基吡啶-5-甲酸为原料，经过7步反应制备2-氨基-2-(2-甲氧基-5-吡啶)乙醇的方法，每步反应产率均高于78%，总收率约为23%，最终产品纯度大于98．5%。
2-氨基-2-(2-甲氧基-5-吡啶)乙醇是一種重要的藥物中間體。本論文提供一種以2-甲氧基吡啶-5-甲痠為原料，經過7步反應製備2-氨基-2-(2-甲氧基-5-吡啶)乙醇的方法，每步反應產率均高于78%，總收率約為23%，最終產品純度大于98．5%。
2-안기-2-(2-갑양기-5-필정)을순시일충중요적약물중간체。본논문제공일충이2-갑양기필정-5-갑산위원료，경과7보반응제비2-안기-2-(2-갑양기-5-필정)을순적방법，매보반응산솔균고우78%，총수솔약위23%，최종산품순도대우98．5%。
The title compound,2-amino-2-(2-methoxypyridin-5-yl)ethanol,is an important pharmaceutical intermediate. In this pa-per,the compound was synthesized by a 7 steps reaction using 2-methoxypyridine-5-carboxylic acid as the raw material. The yield of each reaction step and the total yield was higher than 78%and 23%,respectively. The purity of the final product was greater than 98. 5%.
