CAJ | 학술논문

组织蛋白酶 K（Cathepsin K，CK）是一种溶酶体半胱氨酸蛋白酶，属于番木瓜蛋白酶超家族。在破骨细胞（osteoclast，OC）介导的骨吸收过程中有效降解骨组织中的基质蛋白，在骨吸收过程中发挥重要作用。研究 CK 在骨吸收中的重要性，为治疗骨代谢疾病开辟了新的途径。论文就组织蛋白酶 K 的结构和功能及在骨吸收过程中与破骨细胞的相互作用和表达水平的调控机制进行了阐述。
조직단백매 K（Cathepsin K，CK）시일충용매체반광안산단백매，속우번목과단백매초가족。재파골세포（osteoclast，OC）개도적골흡수과정중유효강해골조직중적기질단백，재골흡수과정중발휘중요작용。연구 CK 재골흡수중적중요성，위치료골대사질병개벽료신적도경。논문취조직단백매 K 적결구화공능급재골흡수과정중여파골세포적상호작용화표체수평적조공궤제진행료천술。
Cathepsin K is one of lysosomal cysteine proteases,belongs to the papaya protease superfamily,highly expressed in the process of bone resorption mediated by osteoclasts and degrade matrix proteins in bone tissue ef-fectively,plays a significant role in the process on bone resorption.Study of the importance of cathepsin k in bone resorption opened up a new approach to metabolic bone disease treatment.In this mini-review,we mainly focused on the structure and function of cathepsin K and the interaction with osteoclast,the regulation mechanisms of ex-pression levels in the process of bone resorption.