CAJ | 학술논문

目的：探讨支气管哮喘患者血清25-羟维生素 D[25（OH）D3]水平与肺功能的相关性。方法选取我院呼吸内科2013年1-10月重度、中度、轻度哮喘患者各13例，另选择我院同期健康体检者15名为对照组，分别进行血清25（OH）D3和肺功能指标的检测，计算第1秒用力呼气容积占预计值百分比（FEV1％ pred）。结果轻度组、中度组和重度组患者 FEV1％ pred 分别为（86.62±10.80）％、（67.23±11.30）％和（31.26±12.80）％，两两比较差异均有统计学意义（P 均＜0.01）；对照组与轻度、中度和重度支气管哮喘组25（OH）D3分别为（17.28±7.12）、（14.33±6.82）、（10.28±5.51）、（5.68±3.26）μg/ L，两两比较差异均有统计学意义（P ＜0.01或0.05）。支气管哮喘患者血清25（OH）D3水平（y）与肺功能（x）呈直线正相关，直线回归方程：y =-0.0115+0.167x。结论维生素 D 缺乏与支气管哮喘的发病及病情程度相关，补充维生素 D 也应作为支气管哮喘患者的一种治疗手段。
목적：탐토지기관효천환자혈청25-간유생소 D[25（OH）D3]수평여폐공능적상관성。방법선취아원호흡내과2013년1-10월중도、중도、경도효천환자각13례，령선택아원동기건강체검자15명위대조조，분별진행혈청25（OH）D3화폐공능지표적검측，계산제1초용력호기용적점예계치백분비（FEV1％ pred）。결과경도조、중도조화중도조환자 FEV1％ pred 분별위（86.62±10.80）％、（67.23±11.30）％화（31.26±12.80）％，량량비교차이균유통계학의의（P 균＜0.01）；대조조여경도、중도화중도지기관효천조25（OH）D3분별위（17.28±7.12）、（14.33±6.82）、（10.28±5.51）、（5.68±3.26）μg/ L，량량비교차이균유통계학의의（P ＜0.01혹0.05）。지기관효천환자혈청25（OH）D3수평（y）여폐공능（x）정직선정상관，직선회귀방정：y =-0.0115+0.167x。결론유생소 D 결핍여지기관효천적발병급병정정도상관，보충유생소 D 야응작위지기관효천환자적일충치료수단。
Objective To investigate the relationship between serum 25- hydroxyvitamin D(25(OH) D3)level and lung function of bronchial asthma patients. Methods Thirty-nine bronchial asthma patients with severe,moderate,mild stage(each for 13 cases)in respiratory department of the First People's Hospital of Jining from Jan. to Oct. 2013 were selected as our subjects. Fifth healthy people were selected as control group. Serum 25(OH)D3 and pulmonary function indexes were detected,and the percentage of forced expiratory volume in one second(FEV)in predicted value(FEV1% pred)was calculated. Results The FEV1% pred of patients with mild,moderate and severe stage bronchial asthma were(86. 62 ± 10. 80)% ,(67. 23 ± 11. 30)% and(31. 26 ± 12. 80)% pespectively,and there were significant between groups(P < 0. 01). The level of 25(OH)D3 in patients with mild,moderate and severe bronchial asthma were(14. 33 ± 6. 82),(10. 28 ± 5. 51),(5. 68 ± 3. 26)μg/ L respectively,lower than that in control group((17. 28 ± 7. 12)μg/ L),and the differences were statistically significant(P < 0. 01 or 0. 05). There was a positive correlation between serum 25(OH)D3 and pulmonary function,and the linear regression equation was:y = - 0. 0115 + 0. 167x. Conclusion The deficiency of Vitamin D relate to the occrrence and degreed of bronchial asthmaisease,and suppliment of vitamin D should also be used as a therapy in patients with bronchial asthma.