CAJ | 학술논문

目的：观察多巴丝肼联合 dl-3-正丁基苯酞胶囊对脑卒中患者患侧肢体功能的影响。方法将90例脑卒中偏瘫患者采用随机数字表法分为康复组、治疗组及对照组，每组30例。前两组患者均给予运动疗法，治疗组患者加用口服多巴丝肼及 dl-3-正丁基苯酞胶囊治疗，对照组仅给予安慰剂口服治疗。分别于治疗前、治疗8周时采用成人偏瘫运动功能评分（FMA）和运动功能评估量表（MAS）对患者下肢功能进行评定。结果治疗前3组患者下肢 FMA[康复组（22.6±3.6）分，治疗组（23.1±2.5）分，对照组（20.3±2.9）分]和 MAS 评分[分别为（1.6±0.6）、（2.1±0.5）、（1.7±0.9）分]差异均无统计学意义（F =1.64，P ＞0.05；F =1.66，P ＞0.05）；治疗8周后，康复组和治疗组患者下肢 FMA[（60.6±3.5）分、（75.7±4.5）分]及 MAS[（14.6±1.1）分、（17.7±4.5）分]评分均较治疗前改善（t 值分别为1.738、1.732，1.716、1.732，P 均＜0.05），治疗组较康复组改善（ P 均＜0.05），且两组均优于对照组[（31.0&nbsp；±3.6）、（5.5±1.1）分]，差异均有统计学意义（P 均＜0.05）。结论多巴丝肼联合 dl-3-正丁基苯酞胶囊可进一步改善脑卒中患者患侧肢体功能。
목적：관찰다파사정연합 dl-3-정정기분태효낭대뇌졸중환자환측지체공능적영향。방법장90례뇌졸중편탄환자채용수궤수자표법분위강복조、치료조급대조조，매조30례。전량조환자균급여운동요법，치료조환자가용구복다파사정급 dl-3-정정기분태효낭치료，대조조부급여안위제구복치료。분별우치료전、치료8주시채용성인편탄운동공능평분（FMA）화운동공능평고량표（MAS）대환자하지공능진행평정。결과치료전3조환자하지 FMA[강복조（22.6±3.6）분，치료조（23.1±2.5）분，대조조（20.3±2.9）분]화 MAS 평분[분별위（1.6±0.6）、（2.1±0.5）、（1.7±0.9）분]차이균무통계학의의（F =1.64，P ＞0.05；F =1.66，P ＞0.05）；치료8주후，강복조화치료조환자하지 FMA[（60.6±3.5）분、（75.7±4.5）분]급 MAS[（14.6±1.1）분、（17.7±4.5）분]평분균교치료전개선（t 치분별위1.738、1.732，1.716、1.732，P 균＜0.05），치료조교강복조개선（ P 균＜0.05），차량조균우우대조조[（31.0&nbsp；±3.6）、（5.5±1.1）분]，차이균유통계학의의（P 균＜0.05）。결론다파사정연합 dl-3-정정기분태효낭가진일보개선뇌졸중환자환측지체공능。
Objective To investigate the effects of levodopa benserazide hydrochloride combine with dl-3-butyl phthalide capsule on patient's limbs function after stroke. Methods Ninety patients with stroke were randomly divided into rehabilitation group,treatment group and control group,and 30 cases for each group. Patients in rehabilitation group were treated with exercise therapy,in treatment group were given exercise therapy and levodopa Benserazide and Dl-3-butylphthalide capsules,and in control group were given placebo treatment. Adult hemiplegic motor function score(FMA)and motor function assessment scale(MAS)were used to assess the motor function and lower extremity function before treatment and 8 weeks after treatment. Results Before treatment,FMA and MAS in rehabilitation group,treatment group and control group were(22. 6 ± 3. 6), (23. 1 ± 2. 5)and(20. 3 ± 2. 9),and(1. 6 ± 0. 6),(2. 1 ± 0. 5),(1. 7 ± 0. 9),respectively. There was no significant differences between the two groups( F = 1. 64,P > 0. 05;F = 1. 66,P > 0. 05). After 8 weeks of treatment,FMA and MAS in rehabilitation group and treatment group were(60. 6 ± 3. 5),(14. 6 ± 1. 1),and (75. 7 ± 4. 5),(17. 7 ± 4. 5),significant improved more than that before treatment(t = 1. 738,1,716,1. 732 respectively;P < 0. 05). Meanwhile,patients in the treatment group improved more than that in rehabilitation group(P < 0. 05),and they were superior to patients in control group((31. 0 ± 3. 6),(5. 5 ± 1. 1);P < 0. 05). Conclusion Benserazide combined with dl-3- butyl phthalide capsule can further improve the limbs function.