中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
7期
678-680
,共3页
田国祥%张薇%武云涛%王玉言%魏万林
田國祥%張薇%武雲濤%王玉言%魏萬林
전국상%장미%무운도%왕옥언%위만림
糖尿病%心脏舒张功能%动脉僵硬度%心踝血管指数
糖尿病%心髒舒張功能%動脈僵硬度%心踝血管指數
당뇨병%심장서장공능%동맥강경도%심과혈관지수
Diabetes%Cardiac diastolic function%Arterial stiffness%Cardio ankle vascular index
目的:探讨2型糖尿病患者左心室舒张功能与动脉僵硬度的相关性。方法选取2012年1月至2013年12月在北京军区总医院住院治疗的2型糖尿病患者102例(糖尿病组),同期住院治疗的非糖尿病患者126例作为对照组。采集入组患者的病史并检测血脂、血糖等生化指标,采用 VS-1000动脉硬化检测仪测定心踝血管指数( CAVI),超声心动图测定左心室舒张功能指标,包括左心房内径(LAD)、左心室舒张早期流速峰值( E)、左心室舒张晚期流速峰值( A)、E/ A 比值及 E 峰减速时间(EDT)。比较两组患者左心室舒张功能、CAVI 水平等指标的差异并进行相关性分析。结果糖尿病组患者 LAD、A、EDT、CAVI 水平显著高于对照组[LAD 分别为[(39.5±5.3)mm 与(34.4±4.2)mm;A 分别为(76.6±13.5)cm/ s 与(71.3±13.4)cm/ s;EDT 分别为(206.6±56.3)ms 与(185.5±34.4)ms;CAVI 分别为9.6±1.1与8.5±0.9];而 E、E/ A 水平显著低于对照组[E 分别为[(56.6±20.4)cm/ s 与(67.5±16.4)cm/ s;E/ A 分别为0.73±0.21与0.96±0.26],两组比较差异均有统计学意义(P 值分别为0.001、0.004、0.002、0.001、0.001、0.001)。在校正了体质量指数、甘油三酯等相关因素后 CAVI 仍与E/ A 呈负相关(r =-0.339,P <0.05),与 EDT 呈正相关(r =0.314,P <0.05)。结论糖尿病患者心脏舒张功能减低,动脉僵硬度增加,两者呈负相关。
目的:探討2型糖尿病患者左心室舒張功能與動脈僵硬度的相關性。方法選取2012年1月至2013年12月在北京軍區總醫院住院治療的2型糖尿病患者102例(糖尿病組),同期住院治療的非糖尿病患者126例作為對照組。採集入組患者的病史併檢測血脂、血糖等生化指標,採用 VS-1000動脈硬化檢測儀測定心踝血管指數( CAVI),超聲心動圖測定左心室舒張功能指標,包括左心房內徑(LAD)、左心室舒張早期流速峰值( E)、左心室舒張晚期流速峰值( A)、E/ A 比值及 E 峰減速時間(EDT)。比較兩組患者左心室舒張功能、CAVI 水平等指標的差異併進行相關性分析。結果糖尿病組患者 LAD、A、EDT、CAVI 水平顯著高于對照組[LAD 分彆為[(39.5±5.3)mm 與(34.4±4.2)mm;A 分彆為(76.6±13.5)cm/ s 與(71.3±13.4)cm/ s;EDT 分彆為(206.6±56.3)ms 與(185.5±34.4)ms;CAVI 分彆為9.6±1.1與8.5±0.9];而 E、E/ A 水平顯著低于對照組[E 分彆為[(56.6±20.4)cm/ s 與(67.5±16.4)cm/ s;E/ A 分彆為0.73±0.21與0.96±0.26],兩組比較差異均有統計學意義(P 值分彆為0.001、0.004、0.002、0.001、0.001、0.001)。在校正瞭體質量指數、甘油三酯等相關因素後 CAVI 仍與E/ A 呈負相關(r =-0.339,P <0.05),與 EDT 呈正相關(r =0.314,P <0.05)。結論糖尿病患者心髒舒張功能減低,動脈僵硬度增加,兩者呈負相關。
목적:탐토2형당뇨병환자좌심실서장공능여동맥강경도적상관성。방법선취2012년1월지2013년12월재북경군구총의원주원치료적2형당뇨병환자102례(당뇨병조),동기주원치료적비당뇨병환자126례작위대조조。채집입조환자적병사병검측혈지、혈당등생화지표,채용 VS-1000동맥경화검측의측정심과혈관지수( CAVI),초성심동도측정좌심실서장공능지표,포괄좌심방내경(LAD)、좌심실서장조기류속봉치( E)、좌심실서장만기류속봉치( A)、E/ A 비치급 E 봉감속시간(EDT)。비교량조환자좌심실서장공능、CAVI 수평등지표적차이병진행상관성분석。결과당뇨병조환자 LAD、A、EDT、CAVI 수평현저고우대조조[LAD 분별위[(39.5±5.3)mm 여(34.4±4.2)mm;A 분별위(76.6±13.5)cm/ s 여(71.3±13.4)cm/ s;EDT 분별위(206.6±56.3)ms 여(185.5±34.4)ms;CAVI 분별위9.6±1.1여8.5±0.9];이 E、E/ A 수평현저저우대조조[E 분별위[(56.6±20.4)cm/ s 여(67.5±16.4)cm/ s;E/ A 분별위0.73±0.21여0.96±0.26],량조비교차이균유통계학의의(P 치분별위0.001、0.004、0.002、0.001、0.001、0.001)。재교정료체질량지수、감유삼지등상관인소후 CAVI 잉여E/ A 정부상관(r =-0.339,P <0.05),여 EDT 정정상관(r =0.314,P <0.05)。결론당뇨병환자심장서장공능감저,동맥강경도증가,량자정부상관。
Objective To investigate the association between left ventricular diastolic function and arterial stiffness in patients with type 2 diabetes mellitus. Methods One hundred and two patients with type 2 diabetes( diabetic group),and 126 non-diabetic patients( control group) were selected from Jan. 2012 to Dec. 2013 in the Beijing Military General Hospital. The clinical features were recorded and free blood glucose (FBG ),blood lipids were measured. Cardio ankle vascular index( CAVI ) was measured by VS-1000 arteriosclerosis detector. Ultrasound heartbeat diagram was used to determine the left ventricular diastolic function indexes including the left atrial diameter(LAD),left ventricular early diastolicpeak velocity(E),left ventricular diastolic peak velocity(A),E/ A ratio and E peak deceleration time(EDT). Results The level of LAD,A, EDT,CAVI in diabetic patients were(39. 5 ± 5. 3)mm,(76. 6 ± 13. 5)cm/ s,(206. 6 ± 56. 3)ms,(9. 6 ± 1. 1)respectively,higher than those in control group((34. 4 ± 4. 2)mm,(71. 3 ± 13. 4)cm/ s,(185. 5 ± 34. 4)ms,(8. 5 ± 0. 9)). And E,E/ A level in diabetic group were(56. 6 ± 20. 4)cm/ s and(0. 73 ± 0. 21),significantly lower than the control group((67. 5 ± 16. 4)cm/ s and(0. 96 ± 0. 26)). The differences between the two groups were significant(P = 0. 001,0. 004,0. 002,0. 001,0. 001,0. 001). After adjusting the factors including body mass index and triglyceride,CAVI was negatively correlated with E/ A(r = - 0. 339,P< 0. 05))and positively correlated with EDT(r = 0. 314,P < 0. 05). Conclusion The diabetic patients with lower diastolic function and higher arterial stiffness,and the two factors are negatively correlation.