北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2014年
6期
447-449
,共3页
田树萍%何菡%王文静%娄金丽
田樹萍%何菡%王文靜%婁金麗
전수평%하함%왕문정%루금려
手足口病%肠道病毒71型%柯萨奇病毒A组16型%肠道病毒未分型
手足口病%腸道病毒71型%柯薩奇病毒A組16型%腸道病毒未分型
수족구병%장도병독71형%가살기병독A조16형%장도병독미분형
Hand-foot-mouth disease (HFMD)%Enterovirus 71 (EV71)%Coxsackievirus A16 (CA16)%Un-classified enteroviruses
目的：探讨2011-2013年手足口病（HFMD）病原体变化趋势。方法采集4064例在我院就诊的HFMD患者的咽拭子标本并提取核酸，采用实时荧光定量PCR方法检测肠道病毒通用型（EV），肠道病毒71型（EV71）及柯萨奇病毒A组16型（CA16）。结果3年间6岁以上患儿占96.0%；发病以5~7月份为主，占73.5%。2011-2013年HFMD 患者 EV71、CA16和未分型肠道病毒的检出率依次为42.6%、35.3%、18.5%，16.1%、22.6%、11.5%，41.3%、42.1%、70.0%，差异有统计学意义（掊2=343.3，P＜0.05）。2013年EV71、CA16检出率明显低于2011、2012年，未分型病毒检出率明显增高（P均＜0.017）。613例重症HFMD患儿中，EV71感染占59.2%、CA16感染占11.1%，未分型病毒感染占29.7%，且均以肺炎合并脑干脑炎为主。结论2011-2013年HFMD病原谱发生了变化，未分型肠道病毒增多，需引起重视。
目的：探討2011-2013年手足口病（HFMD）病原體變化趨勢。方法採集4064例在我院就診的HFMD患者的嚥拭子標本併提取覈痠，採用實時熒光定量PCR方法檢測腸道病毒通用型（EV），腸道病毒71型（EV71）及柯薩奇病毒A組16型（CA16）。結果3年間6歲以上患兒佔96.0%；髮病以5~7月份為主，佔73.5%。2011-2013年HFMD 患者 EV71、CA16和未分型腸道病毒的檢齣率依次為42.6%、35.3%、18.5%，16.1%、22.6%、11.5%，41.3%、42.1%、70.0%，差異有統計學意義（掊2=343.3，P＜0.05）。2013年EV71、CA16檢齣率明顯低于2011、2012年，未分型病毒檢齣率明顯增高（P均＜0.017）。613例重癥HFMD患兒中，EV71感染佔59.2%、CA16感染佔11.1%，未分型病毒感染佔29.7%，且均以肺炎閤併腦榦腦炎為主。結論2011-2013年HFMD病原譜髮生瞭變化，未分型腸道病毒增多，需引起重視。
목적：탐토2011-2013년수족구병（HFMD）병원체변화추세。방법채집4064례재아원취진적HFMD환자적인식자표본병제취핵산，채용실시형광정량PCR방법검측장도병독통용형（EV），장도병독71형（EV71）급가살기병독A조16형（CA16）。결과3년간6세이상환인점96.0%；발병이5~7월빈위주，점73.5%。2011-2013년HFMD 환자 EV71、CA16화미분형장도병독적검출솔의차위42.6%、35.3%、18.5%，16.1%、22.6%、11.5%，41.3%、42.1%、70.0%，차이유통계학의의（부2=343.3，P＜0.05）。2013년EV71、CA16검출솔명현저우2011、2012년，미분형병독검출솔명현증고（P균＜0.017）。613례중증HFMD환인중，EV71감염점59.2%、CA16감염점11.1%，미분형병독감염점29.7%，차균이폐염합병뇌간뇌염위주。결론2011-2013년HFMD병원보발생료변화，미분형장도병독증다，수인기중시。
Objective To study the pathogenic characteristics of hand-foot-mouth disease (HFMD)by detecting the specimens isolated from the patients during 2011-2013, and to observe the new trend of this disease. Methods A total of 4 064 clinical specimens were collected from HFMD patients and then viral isolations were performed, the positive viral isolates were identified by using the real-time PCR method(detecting EV, EV71 and CA16). Results The ration of chil-dren under 6 years old was 96.0%. The amount of patients in May to July occupied 73.5% in the 3 years.The detection rates between EV71, CA16 and unclassified enteroviruses were statistical significance during those 3 years (x2=343.3, P<0.05). The detection rate of EV71, CA16 in 2013 was significantly lower than 2011 and 2012, the detection rate of unclas-sified enteroviruses in 2013 was significantly higher than 2011 and 2012 (all P< 0.017). In the 613 serious HFMD chil-dren, EV71 infection was 59.2%, CA16 infection was 11.1%, and unclassified enteroviruses infection was 29.7%. Conclu-sion The pathogenic characteristics of HFMD has changed during the 3 years. Patients infected with unclassified en-teroviruses have increased.More attention should be paid to these patients.
