CAJ | 학술논문

目的：探讨人类博卡病毒（HBoV）致成人急性呼吸道感染（ARI）的临床特征，分析成人病毒性肺炎与HBoV感染的相关性。方法收集2013年5月至2014年1月在北京中医药大学东方医院感染科发热门诊就诊的81例ARI患者的鼻咽拭子，应用多重RT-PCR及PCR技术进行HBoV、呼吸道合胞病毒（RSV）、腺病毒（ADV）、鼻病毒（RhV）、流感病毒（Flu）、副流感病毒（PIV）、人类偏肺病毒（hMPV）、人冠状病毒（HCoV）、肠道病毒等9种病毒及肺炎支原体、肺炎衣原体的核酸检测，分析HBoV致成人ARI的临床特点。结果 HBoV阳性14例（17.3％），其中10例（71.4%）为肺炎，4例（28.6%）为上呼吸道感染。 HBoV单独感染10例，混合感染4例。 HBoV感染者咳嗽10例（71.4%），咳嗽伴喘憋1例（7.1%），咯痰6例（42.9%），发热14例（100.0%），肺部闻及湿性啰音者4例（28.6%）。外周血白细胞正常或降低者11例（78.6%），升高者3例（21.4%）。10例肺炎患者胸部X线片表现为斑片状模糊影9例，大片致密影1例。单侧肺炎7例，双侧肺炎3例，病变均位于中下肺叶。重症肺炎1例，为HBoV混合感染ADV及肺炎支原体。结论 HBoV是引起成人ARI的病原体之一，感染部位以下呼吸道为主。
목적：탐토인류박잡병독（HBoV）치성인급성호흡도감염（ARI）적림상특정，분석성인병독성폐염여HBoV감염적상관성。방법수집2013년5월지2014년1월재북경중의약대학동방의원감염과발열문진취진적81례ARI환자적비인식자，응용다중RT-PCR급PCR기술진행HBoV、호흡도합포병독（RSV）、선병독（ADV）、비병독（RhV）、류감병독（Flu）、부류감병독（PIV）、인류편폐병독（hMPV）、인관상병독（HCoV）、장도병독등9충병독급폐염지원체、폐염의원체적핵산검측，분석HBoV치성인ARI적림상특점。결과 HBoV양성14례（17.3％），기중10례（71.4%）위폐염，4례（28.6%）위상호흡도감염。 HBoV단독감염10례，혼합감염4례。 HBoV감염자해수10례（71.4%），해수반천별1례（7.1%），각담6례（42.9%），발열14례（100.0%），폐부문급습성라음자4례（28.6%）。외주혈백세포정상혹강저자11례（78.6%），승고자3례（21.4%）。10례폐염환자흉부X선편표현위반편상모호영9례，대편치밀영1례。단측폐염7례，쌍측폐염3례，병변균위우중하폐협。중증폐염1례，위HBoV혼합감염ADV급폐염지원체。결론 HBoV시인기성인ARI적병원체지일，감염부위이하호흡도위주。
Objective To investigate the clinical features of HBoV infection in adult patients with acute respiratory infections. Methods The secretion specimens of deep nasal pharynx were collected from 81 patients with acute respiratory infections during May, 2013 to Janurary, 2014. By multiplex RT-PCR and PCR ,HBoV, respiratory syncytial virus (RSV), adenovirus, rhinovirus, influenza virus A and B, para-influenza virus, human metapneumovirus, human coronavirus, enteric virus, mycoplasma and chlamydia were tested. The clinical features of patients with HBoV infection were analyzed. Results Fourteen cases were found with positive human bocavirus, the detective rate was 17.3%. Among them, 10 cases (71.4%) were pneumonia, the other 4 cases (28.6%) were upper respiratory infections. In 10 cases (71.4%), HBoV was the only pathogen detected.The rate of co-infection of HBoV and adenovirus or mycoplasma or influenza virus was 28.6%. The main clinical features included cough (71.4%), wheezing(7.1%), sputum(42.9%)and fever(100.0%). Four(28.6%) cases were found with moist rales. Normal or decreased leukocytes count occurred in 11 cases (78.6%). There was patchy shadows on X-ray in 10 (71.4%) pneumonia patients. Only 1 patient who got co-infection of HBoV, adenovirus and mycoplasma had severe pneumonia. Conculsion HBoV is one of the viral pathogens in adult with respiratory infection.Most of HBoV can cause low respiratory tract infection.