CAJ | 학술논문

目的：对比研究玻璃酸钠联合乙哌立松与单用玻璃酸钠或者单用乙哌立松治疗早中期膝关节骨关节炎的临床疗效。方法门诊选取膝关节骨关节炎患者99例，随机分组，单盲给药，玻璃酸钠治疗组、乙哌立松治疗组和玻璃酸钠结合乙哌立松治疗组各33例，玻璃酸钠结合乙哌立松治疗组予玻璃酸钠关节腔注射及乙哌立松口服治疗，另两组分别单独予玻璃酸钠关节腔注射和乙哌立松口服治疗。比较3组用药后临床症状改善情况及软骨磨损严重程度并作统计学分析。结果经5周治疗后，WOMAC 评分玻璃酸钠结合乙哌立松治疗组均显著低于两单独用药组；尿中 CTX-Ⅱ水平玻璃酸钠结合乙哌立松治疗组明显低于两单独用药组，差异有显著性（P ＜0．05）。结论通过2种不同药理作用的联合---玻璃酸钠的黏弹性充填作用与乙哌立松的缓解疼痛及痉挛作用，可使对膝关节骨关节炎的临床疗效明显优于单药应用。
목적：대비연구파리산납연합을고립송여단용파리산납혹자단용을고립송치료조중기슬관절골관절염적림상료효。방법문진선취슬관절골관절염환자99례，수궤분조，단맹급약，파리산납치료조、을고립송치료조화파리산납결합을고립송치료조각33례，파리산납결합을고립송치료조여파리산납관절강주사급을고립송구복치료，령량조분별단독여파리산납관절강주사화을고립송구복치료。비교3조용약후림상증상개선정황급연골마손엄중정도병작통계학분석。결과경5주치료후，WOMAC 평분파리산납결합을고립송치료조균현저저우량단독용약조；뇨중 CTX-Ⅱ수평파리산납결합을고립송치료조명현저우량단독용약조，차이유현저성（P ＜0．05）。결론통과2충불동약리작용적연합---파리산납적점탄성충전작용여을고립송적완해동통급경련작용，가사대슬관절골관절염적림상료효명현우우단약응용。
Objective To compared the efficacy of hyaluronan combined with eperisone hy-drochloride or simple application of hyaluronan or eperisone hydrochloride in the treatment of pa-tients with knee osteoarthritis (OA).Methods 99 patients with knee OA were randomly divided into hyaluronan group,eperisone hydrochloride group and combined group (hyaluronan combined with eperisone hydrochloride),33 cases in each group.Efficacy was compared among 3 groups. Rsults 5 weeks after treatment,WOMAC score of combined group was significantly higher than hyaluronan group and eperisone hydrochloride group.The CTX-Ⅱ content of urine in combined group was significantly lower than the other two groups (P <0.05).Conclusion Combination of hyaluronan and eperisone hydrochloride can significantly improve the clinical symptoms of patients with knee OA,and its efficacy is obviously better than simple application of hyaluronan or eperisone hydrochloride.