CAJ | 학술논문

目的：探讨血清铁蛋白（SF）在男性2型糖尿病大血管病变发生中的临床价值。方法回顾性分析2013年7月-2014年1月本院内分泌科住院的70例男性2型糖尿病患者的临床资料，分为有颈动脉病变组和颈动脉正常组，比较2组间各指标差异并进行多因素 Logistic 回归分析。结果①与颈动脉正常组比较，颈动脉病变组 SF 水平显著高，2组差异有统计学意义；②通过 Spearman 相关分析表明，血 SF 水平与颈动脉病变、体质指数、糖化血红蛋白、甘油三酯、胰岛素抵抗指数等呈显著正相关（P ＜0．05），与高密度脂蛋白呈显著负相关（P ＜0．05），与低密度脂蛋白、总胆固醇等无显著相关性。结论SF 升高与男性2型糖尿病动脉粥样硬化的发生、发展呈正相关，SF 在男性2型糖尿病大血管病变发生中具有一定的临床价值。
목적：탐토혈청철단백（SF）재남성2형당뇨병대혈관병변발생중적림상개치。방법회고성분석2013년7월-2014년1월본원내분비과주원적70례남성2형당뇨병환자적림상자료，분위유경동맥병변조화경동맥정상조，비교2조간각지표차이병진행다인소 Logistic 회귀분석。결과①여경동맥정상조비교，경동맥병변조 SF 수평현저고，2조차이유통계학의의；②통과 Spearman 상관분석표명，혈 SF 수평여경동맥병변、체질지수、당화혈홍단백、감유삼지、이도소저항지수등정현저정상관（P ＜0．05），여고밀도지단백정현저부상관（P ＜0．05），여저밀도지단백、총담고순등무현저상관성。결론SF 승고여남성2형당뇨병동맥죽양경화적발생、발전정정상관，SF 재남성2형당뇨병대혈관병변발생중구유일정적림상개치。
Objective To explore the clinical value of serum ferritin (SF)in occurrence of macroangiopathy in male patients with type 2 diabetes mellitus (T2DM).Methods Clinical mate-rials of 70 male patients with T2DM were analyzed retrospectively.Differences between two groups (T2DM with carotid artery disease and T2DM without carotid artery disease)were compare and analyzed by multivariable Logistic regression.Results Compare with T2DM without carotid artery disease group,the level of SF significantly increased in carotid artery disease group.Spear-man analysis showed that the level of SF had a remarkable positive correlation with carotid artery disease,body mass index,hemoglobin A1C,triglyceride and index of insulin resistance respectively (P <0.05)and a negative correlation with high density lipoprotein(P <0.05).However,there was no correlation between SF level,low density lipoprotein and total cholesterol.Conclusion In-creasing SF level is positively correlated with the development of atherosclerosis in male patients with T2DM,which can be used to reflect the macroangiopathy in male patients with T2DM.