中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
29期
42-43
,共2页
老年类风湿关节炎%雷公藤%小剂量强的松
老年類風濕關節炎%雷公籐%小劑量彊的鬆
노년류풍습관절염%뢰공등%소제량강적송
Senile rheumatoid arthritis%Tripterygium wilfordii%Small dose of prednisone
目的：观察雷公藤联合小剂量强的松治疗老年类风湿关节炎(RA)的临床疗效和安全性。方法52例老年RA患者随机分为治疗组和对照组；治疗组(26例)口服雷公藤和小剂量强的松治疗，对照组(26例)口服雷公藤治疗，比较治疗前后两组患者临床症状和实验室指标的变化。结果治疗3个月后治疗组患者在晨僵时间、关节压痛数、关节肿胀数、患者VAS评分、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、DAS28指标上改善优于对照组(P<0.05)，且两组治疗3个月后各项指标与治疗前比较，差异有统计学意义(P<0.05)；治疗组患者ACR20、ACR50、ACR70缓解率优于对照组(P<0.05)；两组不良反应发生率比较差异无统计学意义(P>0.05)。结论雷公藤联合小剂量强的松治疗老年类风湿关节炎能快速改善临床症状和实验室指标，不良反应少。
目的：觀察雷公籐聯閤小劑量彊的鬆治療老年類風濕關節炎(RA)的臨床療效和安全性。方法52例老年RA患者隨機分為治療組和對照組；治療組(26例)口服雷公籐和小劑量彊的鬆治療，對照組(26例)口服雷公籐治療，比較治療前後兩組患者臨床癥狀和實驗室指標的變化。結果治療3箇月後治療組患者在晨僵時間、關節壓痛數、關節腫脹數、患者VAS評分、紅細胞沉降率(ESR)、C反應蛋白(CRP)、類風濕因子(RF)、DAS28指標上改善優于對照組(P<0.05)，且兩組治療3箇月後各項指標與治療前比較，差異有統計學意義(P<0.05)；治療組患者ACR20、ACR50、ACR70緩解率優于對照組(P<0.05)；兩組不良反應髮生率比較差異無統計學意義(P>0.05)。結論雷公籐聯閤小劑量彊的鬆治療老年類風濕關節炎能快速改善臨床癥狀和實驗室指標，不良反應少。
목적：관찰뢰공등연합소제량강적송치료노년류풍습관절염(RA)적림상료효화안전성。방법52례노년RA환자수궤분위치료조화대조조；치료조(26례)구복뢰공등화소제량강적송치료，대조조(26례)구복뢰공등치료，비교치료전후량조환자림상증상화실험실지표적변화。결과치료3개월후치료조환자재신강시간、관절압통수、관절종창수、환자VAS평분、홍세포침강솔(ESR)、C반응단백(CRP)、류풍습인자(RF)、DAS28지표상개선우우대조조(P<0.05)，차량조치료3개월후각항지표여치료전비교，차이유통계학의의(P<0.05)；치료조환자ACR20、ACR50、ACR70완해솔우우대조조(P<0.05)；량조불량반응발생솔비교차이무통계학의의(P>0.05)。결론뢰공등연합소제량강적송치료노년류풍습관절염능쾌속개선림상증상화실험실지표，불량반응소。
Objective To observe the clinical effect and safety of tripterygium wilfordii combined with small dose of prednisone in the treatment of senile rheumatoid arthritis (RA).Methods A total of 52 cases of senile RA were randomly divided into treatment group and control group. The treatment group (n=26) received treatment of tripterygium wilfordii and small dose of prednisone, and the control group (n=26) received treatment of tripterygium wilfordii. Clinical symptoms and lab index changes of two groups before and after treatment were compared.Results The stiffness time, joint tenderness count, joint swelling count, patient VAS score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) and DAS28 index of the treatment group patients were better than that of the control group after 3 months (P<0.05). These indexes of the two groups had significant differences, compared with those before the treatment (P<0.05). The ACR20, ACR50 and ACR70 remission rate of the treatment group were better than that of the control group (P<0.05). There was no statistically significance in the difference of adverse reaction rate between the two groups (P>0.05).Conclusion The treatment of tripterygium wilfordii combine with small dose of prednisone in patients with senile rheumatoid arthritis can quickly improve the clinical symptoms and laboratory indexes, and has less adverse reactions.
