CAJ | 학술논문

目的：观察复方樟柳碱穴位注射治疗糖尿病性视网膜病变的临床疗效。方法本研究是前瞻性的对照研究,入选糖尿病性视网膜病变(diabetic retinopathy, DR)Ⅱ期的患者80例80眼,其中治疗组50例50眼,对照组30例30眼。治疗组患者给予复方樟柳碱注射液2 ml作患侧眼的颞浅动脉旁皮下注射,1次/d,共计注射20 d。用药前及用药后30 d分别行Snellen视力表最佳矫正视力(best corrected visual acuity, BCVA)、视网膜振荡电位(oscillatory potenlials, OPS)及对比敏感度(contrastsen sitivity, CS)检查。对照组患者亦给予间隔30 d的上述相同检查。结果 DRⅡ期治疗组患者用药后BCVA有轻度的提高[(0.50±0.16 VS 0.52±0.15),P<0.05]。治疗组患者用药前OPS总振幅(96.7±29.4)μV,用药后(119.5±32.8)μV,差异有统计学意义(P<0.01)。治疗组患者用药后CS检查在低频(1.5 c/d、3.0 c/d)、中频(6.0 c/d)和高频(12.0 c/d、18.0 c/d)均有显著的提高(P<0.01)。对照组患者的BCVA、OPS、CS在30 d内差异无统计学意义(P>0.05)。结论复方樟柳碱穴位注射可显著改善DRⅡ期患者的视网膜血液供应,改善患者的视觉质量,值得在DR患者中早期临床应用。
목적：관찰복방장류감혈위주사치료당뇨병성시망막병변적림상료효。방법본연구시전첨성적대조연구,입선당뇨병성시망막병변(diabetic retinopathy, DR)Ⅱ기적환자80례80안,기중치료조50례50안,대조조30례30안。치료조환자급여복방장류감주사액2 ml작환측안적섭천동맥방피하주사,1차/d,공계주사20 d。용약전급용약후30 d분별행Snellen시력표최가교정시력(best corrected visual acuity, BCVA)、시망막진탕전위(oscillatory potenlials, OPS)급대비민감도(contrastsen sitivity, CS)검사。대조조환자역급여간격30 d적상술상동검사。결과 DRⅡ기치료조환자용약후BCVA유경도적제고[(0.50±0.16 VS 0.52±0.15),P<0.05]。치료조환자용약전OPS총진폭(96.7±29.4)μV,용약후(119.5±32.8)μV,차이유통계학의의(P<0.01)。치료조환자용약후CS검사재저빈(1.5 c/d、3.0 c/d)、중빈(6.0 c/d)화고빈(12.0 c/d、18.0 c/d)균유현저적제고(P<0.01)。대조조환자적BCVA、OPS、CS재30 d내차이무통계학의의(P>0.05)。결론복방장류감혈위주사가현저개선DRⅡ기환자적시망막혈액공응,개선환자적시각질량,치득재DR환자중조기림상응용。
ObjectiveTo observe the clinical effect of compound anisodine hydrobromide through acupoint injection therapy in the treatment of diabetic retinopathy.MethodsThis was a prospective control study of 80 cases of patients (80 eyes) with diabetic retinopathy (DR) Ⅱ period. There were 50 cases (50 eyes) in the treatment group and 30 cases (30 eyes) in the control group. The treatment group was treated by compound anisodine injection 2 ml for superficial temporal artery of the ipsilateral eye next to the subcutaneous injection once a day, and for a total injection of 20 d. The snellen chart of best corrected visual acuity (BCVA), retinal oscillatory potentials (OPS) and contrast sensitivity (CS) were performed in preoperative and postoperative 30 d respectively. All control group patients were also given the same examinations interval of 30 d.ResultsThe treatment group of DR Ⅱ had a slight increase of BCVA [(0.50±0.16 VS 0.52±0.15),P<0.05]. OPS total amplitude of the patients treated with compound anisodine hydrobromide was (96.7±29.4) μV before drug application, and was (119.5±32.8) μV after drug application. The differences were statistically significant (P<0.01). Postoperative CS check of treatment group in the low-frequency (1.5 c/d, 3.0 c/d), middle frequency (6.0 c/d) and high frequency (12.0 c/d, 18.0 c/d) were all significantly improved (P<0.01). The control group had no significant differences in BCVA, OPS and CS examines within 30 d (P>0.05).Conclusions The compound anisodine hydrobromide through acupoint injection can significantly improve the retinal blood supply and visual quality of the DR II patients. It is worthy of applying in patients of DR in the early period.