CAJ | 학술논문

目的：探讨不同诊断类型血吸虫病患者血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)四项参数的变化及其临床意义。方法采用全自动血细胞分析仪及其配套试剂检测68例慢性血吸虫病患者（以下简称“慢血”）、76例晚期血吸虫病患者（以下简称“晚血”，其中巨脾型52例、腹水型24例）以及78例健康对照组的外周血PLT、MPV、PDW、PCT。结果慢血组和晚血组PLT、PCT均明显低于健康对照组（P<0.01），其中晚血组随着病情的进展，肝纤维化程度加深甚至出现肝硬化，其MPV、PDW也发生变化，明显高于对照组，差异有统计学意义（P<0.01）。结论检测血小板各项参数值，可为血吸虫病患者特别是晚血患者病情诊断提供初步评价，对指导临床治疗及判断病人预后有重要意义。
목적：탐토불동진단류형혈흡충병환자혈소판계수(PLT)、혈소판평균체적(MPV)、혈소판분포관도(PDW)、혈소판압적(PCT)사항삼수적변화급기림상의의。방법채용전자동혈세포분석의급기배투시제검측68례만성혈흡충병환자（이하간칭“만혈”）、76례만기혈흡충병환자（이하간칭“만혈”，기중거비형52례、복수형24례）이급78례건강대조조적외주혈PLT、MPV、PDW、PCT。결과만혈조화만혈조PLT、PCT균명현저우건강대조조（P<0.01），기중만혈조수착병정적진전，간섬유화정도가심심지출현간경화，기MPV、PDW야발생변화，명현고우대조조，차이유통계학의의（P<0.01）。결론검측혈소판각항삼수치，가위혈흡충병환자특별시만혈환자병정진단제공초보평개，대지도림상치료급판단병인예후유중요의의。
Objective To investigate the changes and clinical significance of Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) in patients with different types of schistosomiasis. Methods PLT, MPV, PDW and PCT of 68 patients with chronic schistosomiasis (CS), 76 cases with advanced schistosomiasis (AS, involved 52 cases of splenomegaly type and 24 cases of ascites type) and 78 cases of healthy people were detected by automatic hematology analyzer and reagents. Results The PLT and PCT of CS and AS groups were significantly lower than the healthy people (P<0.01). With the progress of the disease, the degree of liver fibrosis deepened and even hepatocirrhosis occurred in AS group and their MPV and PDW were significantly higher than the healthy people ( P<0.01). Conclusion It can provide a preliminary evaluation of the patients ’condition with schistosomiasis, especially advanced schistosomiasis, and guide the clinical treatment and determine the prognosis of patients by detecting various parameter values of platelet.