中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
2期
167-172
,共6页
骨性关节炎%软骨下骨%成骨细胞%软骨%软骨细胞
骨性關節炎%軟骨下骨%成骨細胞%軟骨%軟骨細胞
골성관절염%연골하골%성골세포%연골%연골세포
osteoarthritis%subchondral bone%osteoblast%cartilage%chondrocyte
骨性关节炎是一种骨组织代谢疾病,软骨下骨成骨细胞直接参与骨性关节炎的病理过程。成骨细胞表达异常的生物学表型与软骨下骨结构和功能改变密切相关,其可使软骨承受更高的应力;软骨下骨成骨细胞产生的代谢调节因子通过骨和软骨间微结构直接促进软骨细胞退变。免疫和脂类代谢通过成骨细胞调节骨组织代谢,参与骨性关节炎病变过程。进一步阐明软骨下骨成骨细胞在骨性关节炎病变过程中的作用和机制,可为骨性关节炎研究和治疗提供新方法和思路。
骨性關節炎是一種骨組織代謝疾病,軟骨下骨成骨細胞直接參與骨性關節炎的病理過程。成骨細胞錶達異常的生物學錶型與軟骨下骨結構和功能改變密切相關,其可使軟骨承受更高的應力;軟骨下骨成骨細胞產生的代謝調節因子通過骨和軟骨間微結構直接促進軟骨細胞退變。免疫和脂類代謝通過成骨細胞調節骨組織代謝,參與骨性關節炎病變過程。進一步闡明軟骨下骨成骨細胞在骨性關節炎病變過程中的作用和機製,可為骨性關節炎研究和治療提供新方法和思路。
골성관절염시일충골조직대사질병,연골하골성골세포직접삼여골성관절염적병리과정。성골세포표체이상적생물학표형여연골하골결구화공능개변밀절상관,기가사연골승수경고적응력;연골하골성골세포산생적대사조절인자통과골화연골간미결구직접촉진연골세포퇴변。면역화지류대사통과성골세포조절골조직대사,삼여골성관절염병변과정。진일보천명연골하골성골세포재골성관절염병변과정중적작용화궤제,가위골성관절염연구화치료제공신방법화사로。
Beside degeneration of cartilage , osteoarthritis ( OA) has been considered as a kind of bone metabol-ic disease.One of the main mechanisms is that osteoblasts of subchondral bone are involved in OA pathophysiology .Un-der complex milieu of mechanical forces and biologic exchange , subchondral OA osteoblasts with abnormal phenotype play a key role in the remodeling and structural change of subchondral bone .Stiffened and less pliable subchondral bone can transmit the increased load to overlying cartilage and lead to secondary cartilage loss and degeneration .Moreover , media-tors produced by osteoblasts can promote degeneration of chondrocytes through biological exchange between bone and the overlying cartilage .Furthermore , osteoblasts play an important role in linking bone and fat metabolism with bone metabo-lism.Therefore, A further exploration on the role and patho-mechanism of osteoblasts in OA will provide a great help for the research and therapy of OA .