中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
2期
138-143
,共6页
韩婷%王知笑%孙敏%杨涛%黄晓萍%何畏
韓婷%王知笑%孫敏%楊濤%黃曉萍%何畏
한정%왕지소%손민%양도%황효평%하외
血清25-羟维生素D%维生素D缺乏
血清25-羥維生素D%維生素D缺乏
혈청25-간유생소D%유생소D결핍
serum 25-hydroxy vitamin D%hypovitanmiosis D
目的:了解南京市居民血清维生素D水平,为骨质疏松防治提供依据。方法2011年6月至11月招募南京市城区≥40岁居民2786名,其中40~49岁490人(17.6%),50~59岁1084人(38.9%),60~69岁912人(32.7%),70~78岁300人(10.8%)。采集受试者清晨空腹静脉血,应用酶联免疫法测定血清25-羟维生素D [25OHD]浓度。以血清25OHD≥50 nmol/L和≥75 nmol/L分别定义为维生素D正常及良好,以血清25OHD<25 nmol/L定义为维生素D缺乏,评估南京城区居民血清维生素D水平。采用超声骨密度仪(QUS),用超声振幅衰减(BUA)值及超声声速(SOS)值推算骨密度(BMD)。结果南京城区部分居民血清25OHD平均水平为(44.71±14.68) nmol/L,维生素D正常及良好者分别占31.7%和2.5%。40~49岁组血清25OHD平均为(43.48±14.23) nmol/L,50~59岁组为(45.33±14.49) nmol/L,60~69岁组为(44.41±14.66) nmol/L,70~78岁组为(45.36±15.97) nmol/L,4组间比较差异无统计学意义。血清25OHD缺乏者男性占4.3%(45例),女性占6.7%(117例),差异有统计学意义(P<0.05);受试者BMD水平平均为(0.491±0.112) g/cm2, BMD和血清25OHD浓度呈正相关,差异有统计学意义(r=0.038, P=0.047)。结论南京市部分居民普遍存在维生素D缺乏,女性维生素D水平低于男性。
目的:瞭解南京市居民血清維生素D水平,為骨質疏鬆防治提供依據。方法2011年6月至11月招募南京市城區≥40歲居民2786名,其中40~49歲490人(17.6%),50~59歲1084人(38.9%),60~69歲912人(32.7%),70~78歲300人(10.8%)。採集受試者清晨空腹靜脈血,應用酶聯免疫法測定血清25-羥維生素D [25OHD]濃度。以血清25OHD≥50 nmol/L和≥75 nmol/L分彆定義為維生素D正常及良好,以血清25OHD<25 nmol/L定義為維生素D缺乏,評估南京城區居民血清維生素D水平。採用超聲骨密度儀(QUS),用超聲振幅衰減(BUA)值及超聲聲速(SOS)值推算骨密度(BMD)。結果南京城區部分居民血清25OHD平均水平為(44.71±14.68) nmol/L,維生素D正常及良好者分彆佔31.7%和2.5%。40~49歲組血清25OHD平均為(43.48±14.23) nmol/L,50~59歲組為(45.33±14.49) nmol/L,60~69歲組為(44.41±14.66) nmol/L,70~78歲組為(45.36±15.97) nmol/L,4組間比較差異無統計學意義。血清25OHD缺乏者男性佔4.3%(45例),女性佔6.7%(117例),差異有統計學意義(P<0.05);受試者BMD水平平均為(0.491±0.112) g/cm2, BMD和血清25OHD濃度呈正相關,差異有統計學意義(r=0.038, P=0.047)。結論南京市部分居民普遍存在維生素D缺乏,女性維生素D水平低于男性。
목적:료해남경시거민혈청유생소D수평,위골질소송방치제공의거。방법2011년6월지11월초모남경시성구≥40세거민2786명,기중40~49세490인(17.6%),50~59세1084인(38.9%),60~69세912인(32.7%),70~78세300인(10.8%)。채집수시자청신공복정맥혈,응용매련면역법측정혈청25-간유생소D [25OHD]농도。이혈청25OHD≥50 nmol/L화≥75 nmol/L분별정의위유생소D정상급량호,이혈청25OHD<25 nmol/L정의위유생소D결핍,평고남경성구거민혈청유생소D수평。채용초성골밀도의(QUS),용초성진폭쇠감(BUA)치급초성성속(SOS)치추산골밀도(BMD)。결과남경성구부분거민혈청25OHD평균수평위(44.71±14.68) nmol/L,유생소D정상급량호자분별점31.7%화2.5%。40~49세조혈청25OHD평균위(43.48±14.23) nmol/L,50~59세조위(45.33±14.49) nmol/L,60~69세조위(44.41±14.66) nmol/L,70~78세조위(45.36±15.97) nmol/L,4조간비교차이무통계학의의。혈청25OHD결핍자남성점4.3%(45례),녀성점6.7%(117례),차이유통계학의의(P<0.05);수시자BMD수평평균위(0.491±0.112) g/cm2, BMD화혈청25OHD농도정정상관,차이유통계학의의(r=0.038, P=0.047)。결론남경시부분거민보편존재유생소D결핍,녀성유생소D수평저우남성。
Objective To assess vitamin D status in Nanjing urban residents by two kinds of standards . Methods A total of 2786 adults aged 40 years or older in Nanjing urban area were enrolled in this cross-sectional study from June to December 2011.490 (17.6%) of them were between 40~49 years, 1084 (38.9%) between 50~59 years, 912 (32.7%) between 60~69 years, and 300 (10.8%) between 70 ~78 years.Serum 25OHD level was tested using ELISA.We assessed the vitamin D status of the residents by two different standards of classification .Cal-caneal QUS was evaluated by BUA ( dB/MHz ) and SOS ( m/s ) by a Sahara device; T-score were calculated from BUA and SOS.Results The average serum 25OHD level was (44.71 ±14.68 nmol/L);if defining serum 25OHD≥50 nmol/L, ≥75 nmol/L as vitamin D adequate, there were 31.7%and 2.5%subjects with vit D adequuae; the se-rum 25OHD concentration of the 40 ~49 age group was 43.48 ±14.23 nmol/L and 50~59, 60 ~69, 70~78 age group was 45.33 ±14.49 nmol/L, 44.41 ±14.66 nmol/L, 45.36 ±15.97 nmol/L respectively, and there was no sta-tistical difference among the four age groups.The percent of serum 25OHD deficient ( defined as serum 25OHD <25 nmol/L) among men was 4.3%, 6.7 % among women ( P <0.05 ) .The average BMD level was ( 0.491 ±0.112) g/cm2; the BMD level and serum 25OHD concentration were positively correlated.Conclusion The preva-lence of vitamin D insufficiency or deficieny of Nanjing urban residents was common , the level of vitamin D in women were lower than that of men .