中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
2期
127-132
,共6页
李春海%曾钢%娄振凯%叶伟%丁悦%任晋可%陈晋宸
李春海%曾鋼%婁振凱%葉偉%丁悅%任晉可%陳晉宸
리춘해%증강%루진개%협위%정열%임진가%진진신
腰椎融合术%骨质疏松症%唑来膦酸%双膦酸盐
腰椎融閤術%骨質疏鬆癥%唑來膦痠%雙膦痠鹽
요추융합술%골질소송증%서래련산%쌍련산염
lumbar spinal fusion%osteoporosis%zoledronic acid%bisphosphonate
目的:探讨唑来膦酸对骨质疏松患者腰椎融合术后植骨融合的影响。方法回顾性分析2010年1月至2011年3月因腰椎间盘退变性疾病合并绝经后骨质疏松症患者的病例资料共36例。患者均采用后路腰椎板切除减压、椎间及后外侧植骨融合、椎弓根钉棒内固定术。术后1~2周给予唑来膦酸注射液5mg静脉滴注,同时每天补充元素钙1000 mg和维生素D3400 U。比较术前与术后3、6、12个月时功能障碍指数( ODI )评分与骨转换生化标志物变化。比较术前与术后12个月骨密度变化。分析随访期末时的植骨融合情况。结果36例患者均获得随访,平均年龄(63.18±6.97)岁。术前ODI评分平均为(38.36±5.95)分,术后3个月为(14.36±5.22)分,术后6个月为(9.00±6.07)分,术后12个月为(9.18±6.65)分。术后各时间点ODI评分与术前相比差异均有统计学意义(均P<0.05)。术后3、6个月ODI评分持续下降,6个月达平台期,与12个月相比差异无统计学意义( P>0.05)。骨转换生化标志物血清β-Ⅰ型胶原交联羧基末端肽(β-CTX)、Ⅰ型原胶原氨基端前肽(PINP)术后3个月显著降低(P<0.05),6、12个月时缓慢升高,但均保持在绝经后正常范围内。术前髋部和股骨颈骨密度为(0.721±0.16)和(0.687±0.19) g/cm2,术后12个月提高至(0.746±0.16)和(0.714±0.17) g/cm2(P<0.05)。34例患者获得坚实融合,2例未融合,融合率为94.4%(34/36)。结论唑来膦酸抗骨质疏松作用显著,骨质疏松患者术后早期应用唑膦酸对腰椎融合无不利影响。
目的:探討唑來膦痠對骨質疏鬆患者腰椎融閤術後植骨融閤的影響。方法迴顧性分析2010年1月至2011年3月因腰椎間盤退變性疾病閤併絕經後骨質疏鬆癥患者的病例資料共36例。患者均採用後路腰椎闆切除減壓、椎間及後外側植骨融閤、椎弓根釘棒內固定術。術後1~2週給予唑來膦痠註射液5mg靜脈滴註,同時每天補充元素鈣1000 mg和維生素D3400 U。比較術前與術後3、6、12箇月時功能障礙指數( ODI )評分與骨轉換生化標誌物變化。比較術前與術後12箇月骨密度變化。分析隨訪期末時的植骨融閤情況。結果36例患者均穫得隨訪,平均年齡(63.18±6.97)歲。術前ODI評分平均為(38.36±5.95)分,術後3箇月為(14.36±5.22)分,術後6箇月為(9.00±6.07)分,術後12箇月為(9.18±6.65)分。術後各時間點ODI評分與術前相比差異均有統計學意義(均P<0.05)。術後3、6箇月ODI評分持續下降,6箇月達平檯期,與12箇月相比差異無統計學意義( P>0.05)。骨轉換生化標誌物血清β-Ⅰ型膠原交聯羧基末耑肽(β-CTX)、Ⅰ型原膠原氨基耑前肽(PINP)術後3箇月顯著降低(P<0.05),6、12箇月時緩慢升高,但均保持在絕經後正常範圍內。術前髖部和股骨頸骨密度為(0.721±0.16)和(0.687±0.19) g/cm2,術後12箇月提高至(0.746±0.16)和(0.714±0.17) g/cm2(P<0.05)。34例患者穫得堅實融閤,2例未融閤,融閤率為94.4%(34/36)。結論唑來膦痠抗骨質疏鬆作用顯著,骨質疏鬆患者術後早期應用唑膦痠對腰椎融閤無不利影響。
목적:탐토서래련산대골질소송환자요추융합술후식골융합적영향。방법회고성분석2010년1월지2011년3월인요추간반퇴변성질병합병절경후골질소송증환자적병례자료공36례。환자균채용후로요추판절제감압、추간급후외측식골융합、추궁근정봉내고정술。술후1~2주급여서래련산주사액5mg정맥적주,동시매천보충원소개1000 mg화유생소D3400 U。비교술전여술후3、6、12개월시공능장애지수( ODI )평분여골전환생화표지물변화。비교술전여술후12개월골밀도변화。분석수방기말시적식골융합정황。결과36례환자균획득수방,평균년령(63.18±6.97)세。술전ODI평분평균위(38.36±5.95)분,술후3개월위(14.36±5.22)분,술후6개월위(9.00±6.07)분,술후12개월위(9.18±6.65)분。술후각시간점ODI평분여술전상비차이균유통계학의의(균P<0.05)。술후3、6개월ODI평분지속하강,6개월체평태기,여12개월상비차이무통계학의의( P>0.05)。골전환생화표지물혈청β-Ⅰ형효원교련최기말단태(β-CTX)、Ⅰ형원효원안기단전태(PINP)술후3개월현저강저(P<0.05),6、12개월시완만승고,단균보지재절경후정상범위내。술전관부화고골경골밀도위(0.721±0.16)화(0.687±0.19) g/cm2,술후12개월제고지(0.746±0.16)화(0.714±0.17) g/cm2(P<0.05)。34례환자획득견실융합,2례미융합,융합솔위94.4%(34/36)。결론서래련산항골질소송작용현저,골질소송환자술후조기응용서련산대요추융합무불리영향。
Objective To explore the effect of zoledronic acid on lumbar spinal fusion for patients with osteo-porosis .Methods From January 2010 to March 2011, 36 women with postmenopausal osteoporosis suffering from lumbar disc degenerative diseases were analyzed .All patients underwent posterior lumbar discectomy , decompression , intervertebral and posterolateral bone graft fusion and pedicle screw fixation .One to two weeks after surgery , all patients received 5 mg zoledronic acid infusion plus daily element calcium 1000 mg and vitamin D3 400 IU.Compare the ODI scores and biochemical markers of bone turnover before and 3 months、 6 months and 12 months after surgery .The chan-ges of bone mineral density before and 12 months after treatment were also compared .The solid fusion rate was analyzed . Results Thirty-six patients with an average age of 63.18 ±6.97 were followed .The ODI scores of pre-operation, 3 months , 6 months and 12 months after operation were 38.36 ±5.95 , 14.36 ±5.22 , 9.00 ±6.07 and 9.18 ±6.65 .Sig-nificant difference was achieved regarding to the ODI scores at any follow-up time compared with that of pre-operation (P<0.05).The ODI scores declined obviously 3 months and 6 months after surgery, reaching to a plateau at 6 months,showing no significance compared with the scores of 12 months after surgery .The biochemical markers of bone turnover β-C-terminal crosslink of type Ⅰcollagen (β-CTX) , Amino-terminal propeptide of type I collagen ( PINP) decreased sig-nificantly at 3 months ( P<0.05 ) , then increased slightly , remaining in the normal range of post menopause 6 and 12 months after surgery.Bone mineral density of hip and femoral neck were improved from (0.721 ±0.16) and (0.687 ± 0.19) g/cm2 to (0.746 ±0.16) and (0.714 ±0.17) g/cm2 (P<0.05).Thirty-four patients achieved solid fusion, with a fusion rate of 94.4%(34/36).Conclusion The anti-osteoporosis efficacy of zoledronic acid was significant and no negative effect was observed for lumbar spinal fusion .