中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
2期
106-112
,共7页
洪维%朱晓颖%程群%朱汉民%李慧林%杜艳萍%张雪梅%薛思红%唐雯菁
洪維%硃曉穎%程群%硃漢民%李慧林%杜豔萍%張雪梅%薛思紅%唐雯菁
홍유%주효영%정군%주한민%리혜림%두염평%장설매%설사홍%당문정
髋部骨折%肌肉减少症%骨密度
髖部骨摺%肌肉減少癥%骨密度
관부골절%기육감소증%골밀도
hip fracture%sarcopenia%bone mineral density
目的:探讨老年髋部骨折患者肌肉减少症(sarcopenia)及与骨密度下降的关系。方法113例>65岁的老年髋部骨折患者(骨折组)纳入本研究,男性67例,女性46例;同期非髋部骨折老年患者1321例作为对照组,男性654例,女性667例。所有患者均用双能X线骨密度仪( DXA)检测全身身体组成成分(骨量、肌肉含量,脂肪含量)。肌肉减少症的诊断标准:骨骼肌重量指数( SMI)(肢体骨骼肌重量/身高平方, kg/m2)低于同人种健康成年人1个标准差为1级肌肉减少症(class 1),低于2个标准差为2级肌肉减少症(class 2)。根据以上标准将受试者分为肌量正常组:男性 SMI>7.01 kg/m2,女性SMI>5.42 kg/m2; class 1组:男性SMI 6.09~7.01 kg/m2,女性 SMI 4.80~5.42 kg/m2; class2组:男性 SMI≤6.08 kg/m2,女性SMI≤4.79 kg/m2。分析不同组老年髋部骨折患者肌肉减少症的检出率。结果老年髋部骨折患者肌肉减少症检出率明显高于同性别类似年龄人群:骨折组男性肌肉减少症检出率(62.6%)与对照组男性肌肉减少症检出率(12.8%)比较差异有统计学意义( P<0.001),骨折组女性肌肉减少症检出率(13.0%)与非骨折组女性肌肉减少症检出率(4.1%)比较差异有统计学意义(P<0.001);老年女性髋部骨折患者中肌量正常者24例(52.1%), Class 1级者16例(34.7%), Class 2级者6例(13.0%);骨骼肌重量指数与股骨颈骨密度和全身骨密度呈正相关。老年男性髋部骨折患者中肌量正常者9例(13.4%), Class 1级者16例(23.8%), Class 2级者42例(62.6%),骨骼肌重量指数与BMI呈正相关,与年龄呈负相关。结论老年髋部骨折患者肌肉减少症检出率明显高于同龄非骨折者,男性肌少症检出率高于女性。老年女性髋部骨折患者的骨骼肌重量指数与股骨颈和全身骨密度呈正相关,老年男性髋部骨折患者骨骼肌重量指数则与骨密度无明显相关性。应关注骨折患者肌肉减少症的防治。
目的:探討老年髖部骨摺患者肌肉減少癥(sarcopenia)及與骨密度下降的關繫。方法113例>65歲的老年髖部骨摺患者(骨摺組)納入本研究,男性67例,女性46例;同期非髖部骨摺老年患者1321例作為對照組,男性654例,女性667例。所有患者均用雙能X線骨密度儀( DXA)檢測全身身體組成成分(骨量、肌肉含量,脂肪含量)。肌肉減少癥的診斷標準:骨骼肌重量指數( SMI)(肢體骨骼肌重量/身高平方, kg/m2)低于同人種健康成年人1箇標準差為1級肌肉減少癥(class 1),低于2箇標準差為2級肌肉減少癥(class 2)。根據以上標準將受試者分為肌量正常組:男性 SMI>7.01 kg/m2,女性SMI>5.42 kg/m2; class 1組:男性SMI 6.09~7.01 kg/m2,女性 SMI 4.80~5.42 kg/m2; class2組:男性 SMI≤6.08 kg/m2,女性SMI≤4.79 kg/m2。分析不同組老年髖部骨摺患者肌肉減少癥的檢齣率。結果老年髖部骨摺患者肌肉減少癥檢齣率明顯高于同性彆類似年齡人群:骨摺組男性肌肉減少癥檢齣率(62.6%)與對照組男性肌肉減少癥檢齣率(12.8%)比較差異有統計學意義( P<0.001),骨摺組女性肌肉減少癥檢齣率(13.0%)與非骨摺組女性肌肉減少癥檢齣率(4.1%)比較差異有統計學意義(P<0.001);老年女性髖部骨摺患者中肌量正常者24例(52.1%), Class 1級者16例(34.7%), Class 2級者6例(13.0%);骨骼肌重量指數與股骨頸骨密度和全身骨密度呈正相關。老年男性髖部骨摺患者中肌量正常者9例(13.4%), Class 1級者16例(23.8%), Class 2級者42例(62.6%),骨骼肌重量指數與BMI呈正相關,與年齡呈負相關。結論老年髖部骨摺患者肌肉減少癥檢齣率明顯高于同齡非骨摺者,男性肌少癥檢齣率高于女性。老年女性髖部骨摺患者的骨骼肌重量指數與股骨頸和全身骨密度呈正相關,老年男性髖部骨摺患者骨骼肌重量指數則與骨密度無明顯相關性。應關註骨摺患者肌肉減少癥的防治。
목적:탐토노년관부골절환자기육감소증(sarcopenia)급여골밀도하강적관계。방법113례>65세적노년관부골절환자(골절조)납입본연구,남성67례,녀성46례;동기비관부골절노년환자1321례작위대조조,남성654례,녀성667례。소유환자균용쌍능X선골밀도의( DXA)검측전신신체조성성분(골량、기육함량,지방함량)。기육감소증적진단표준:골격기중량지수( SMI)(지체골격기중량/신고평방, kg/m2)저우동인충건강성년인1개표준차위1급기육감소증(class 1),저우2개표준차위2급기육감소증(class 2)。근거이상표준장수시자분위기량정상조:남성 SMI>7.01 kg/m2,녀성SMI>5.42 kg/m2; class 1조:남성SMI 6.09~7.01 kg/m2,녀성 SMI 4.80~5.42 kg/m2; class2조:남성 SMI≤6.08 kg/m2,녀성SMI≤4.79 kg/m2。분석불동조노년관부골절환자기육감소증적검출솔。결과노년관부골절환자기육감소증검출솔명현고우동성별유사년령인군:골절조남성기육감소증검출솔(62.6%)여대조조남성기육감소증검출솔(12.8%)비교차이유통계학의의( P<0.001),골절조녀성기육감소증검출솔(13.0%)여비골절조녀성기육감소증검출솔(4.1%)비교차이유통계학의의(P<0.001);노년녀성관부골절환자중기량정상자24례(52.1%), Class 1급자16례(34.7%), Class 2급자6례(13.0%);골격기중량지수여고골경골밀도화전신골밀도정정상관。노년남성관부골절환자중기량정상자9례(13.4%), Class 1급자16례(23.8%), Class 2급자42례(62.6%),골격기중량지수여BMI정정상관,여년령정부상관。결론노년관부골절환자기육감소증검출솔명현고우동령비골절자,남성기소증검출솔고우녀성。노년녀성관부골절환자적골격기중량지수여고골경화전신골밀도정정상관,노년남성관부골절환자골격기중량지수칙여골밀도무명현상관성。응관주골절환자기육감소증적방치。
mass and fat mass.Sarcopenia was defined as skeletal muscle index (SMI), described as appendicular lean mass index divided by height square .Class 1 and class 2 sarcopenia were defined as 1or2 standard deviations of SMI below the sex-specific means for young adults .Results Compared to the non-fracture group , the prevalence of sarcopenia in elderly patients with hip fracture was signifcant higher ( Hip fracture vs non-fracture group , Male: 62.6% vs 12.8%, P <0.001; female: 13.0%vs 4.1%, P<0.001 ) .In female patients , the prevalence of sarcopenia was 34.7%in Class 1 and 13%in Class 2;SMI was significant correlated with FNBMD and total BMD .In male patients , the prevalence of sar-copenia was 23.8%in Class 1 and 62.6 %in Class 2;SMI was positively correlated with BMI but negatively with age . Conclusion The prevalence of sarcopenia was significantly higher in patients with fracture than those of non -fracture ones.And male elderly patients suffered more sarcopenia to female ones .The prevention and treatment of sarcopenia in patients with hip fracture should be concerned .