CAJ | 학술논문

目的：探讨艾司西酞普兰与氟西汀治疗抑郁症的临床疗效。方法本研究按照随机数字表法将60例患者随机分为研究组和对照组各30例，其中研究组患者采用艾司西酞普兰治疗，而对照组则采用氟西汀治疗，比较两组患者的临床疗效、HAMD评分及不良反应。结果研究组患者治疗2w后即起效，且HAMD评分明显低于对照组，且差异具有统计学意义（P<0.05）。研究组的总有效率明显高于对照组，且差异具有统计学意义（P<0.05）。研究组的不良反应发生率（36.67%）与对照组（40.00%）比较无明显差异（P>0.05）。结论艾司西酞普兰在治疗抑郁症方面，与氟西汀相比临床疗效佳，起效快，安全性好，值得临床推广使用。
목적：탐토애사서태보란여불서정치료억욱증적림상료효。방법본연구안조수궤수자표법장60례환자수궤분위연구조화대조조각30례，기중연구조환자채용애사서태보란치료，이대조조칙채용불서정치료，비교량조환자적림상료효、HAMD평분급불량반응。결과연구조환자치료2w후즉기효，차HAMD평분명현저우대조조，차차이구유통계학의의（P<0.05）。연구조적총유효솔명현고우대조조，차차이구유통계학의의（P<0.05）。연구조적불량반응발생솔（36.67%）여대조조（40.00%）비교무명현차이（P>0.05）。결론애사서태보란재치료억욱증방면，여불서정상비림상료효가，기효쾌，안전성호，치득림상추엄사용。
Objective To study the clinical curative effect between escitalopram and fluoxetine in the treatment of depression. Methods 60 patients were randomly divided into study group and control group, and the study group was treated with escitalopram while the control group with flu-oxetine treatment, comparing the two groups of patients with the clinical efficacy, adverse reactions and HAMD score. Results After treating for 2 weeks, the study group patients took effects fast, and the HAMD score was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). In total efficiency, the study group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05).There was no significant difference (P>0.05) between the study group (36.67%) and control group (40.00%) in the incidence rate of adverse reactions. Conclusion In the treatment of depression,compared with fluoxetine, escitalopram is better, faster and safer in clinical effects, which can be widely used.