中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
11期
157-157,158
,共2页
儿童%腺样体切除术%曲马多%超前镇痛
兒童%腺樣體切除術%麯馬多%超前鎮痛
인동%선양체절제술%곡마다%초전진통
child%adenoidectomy%tramadol%PreemPtive analgesia
目的：观察麻醉前静脉注射曲马多在儿童鼻内窥镜下腺样体切除术的超前镇痛效果。方法选择60例腺样体肥大患儿择期行鼻内窥镜下腺样体切除术，随机均分成曲马多超前镇痛组（T组）与对照组（P组）。于麻醉诱导前T组静脉注射曲马多2 mg/kg，P组静脉注射0.9%氯化纳注射液5 mL，两组患儿均在靶控输注（TCI）盐酸瑞芬太尼复合低浓度异氟烷吸入麻醉下手术。患儿拔除气管导管后送入麻醉后恢复室（PACU），记录此时点起0，2，4，6，12，24 h患儿的疼痛视觉模拟评分（VAS）、Ramsay镇静评分，以及术后恶心呕吐（PONV）发生情况以及药物副作用等。结果0~6 h各时点内T组的VAS评分及Ramsay镇静评分均优于P组（ P<0.05），12~24 h各时点内两组VAS评分及Ramsay镇静评分比较差异无显著性（ P>0.05）。两组均未见严重药品不良反应。结论曲马多可为儿童鼻内窥镜下腺样体切除术提供有效、安全的超前镇痛。
目的：觀察痳醉前靜脈註射麯馬多在兒童鼻內窺鏡下腺樣體切除術的超前鎮痛效果。方法選擇60例腺樣體肥大患兒擇期行鼻內窺鏡下腺樣體切除術，隨機均分成麯馬多超前鎮痛組（T組）與對照組（P組）。于痳醉誘導前T組靜脈註射麯馬多2 mg/kg，P組靜脈註射0.9%氯化納註射液5 mL，兩組患兒均在靶控輸註（TCI）鹽痠瑞芬太尼複閤低濃度異氟烷吸入痳醉下手術。患兒拔除氣管導管後送入痳醉後恢複室（PACU），記錄此時點起0，2，4，6，12，24 h患兒的疼痛視覺模擬評分（VAS）、Ramsay鎮靜評分，以及術後噁心嘔吐（PONV）髮生情況以及藥物副作用等。結果0~6 h各時點內T組的VAS評分及Ramsay鎮靜評分均優于P組（ P<0.05），12~24 h各時點內兩組VAS評分及Ramsay鎮靜評分比較差異無顯著性（ P>0.05）。兩組均未見嚴重藥品不良反應。結論麯馬多可為兒童鼻內窺鏡下腺樣體切除術提供有效、安全的超前鎮痛。
목적：관찰마취전정맥주사곡마다재인동비내규경하선양체절제술적초전진통효과。방법선택60례선양체비대환인택기행비내규경하선양체절제술，수궤균분성곡마다초전진통조（T조）여대조조（P조）。우마취유도전T조정맥주사곡마다2 mg/kg，P조정맥주사0.9%록화납주사액5 mL，량조환인균재파공수주（TCI）염산서분태니복합저농도이불완흡입마취하수술。환인발제기관도관후송입마취후회복실（PACU），기록차시점기0，2，4，6，12，24 h환인적동통시각모의평분（VAS）、Ramsay진정평분，이급술후악심구토（PONV）발생정황이급약물부작용등。결과0~6 h각시점내T조적VAS평분급Ramsay진정평분균우우P조（ P<0.05），12~24 h각시점내량조VAS평분급Ramsay진정평분비교차이무현저성（ P>0.05）。량조균미견엄중약품불량반응。결론곡마다가위인동비내규경하선양체절제술제공유효、안전적초전진통。
Objective To investigate the effect of PreemPtive analgesia of tramadol by intravenous injection in Pediatric adenoidectomy by nasal endoscoPy. Methods 60 children Patients with adenoidal hyPertroPhy undergoing elective adenoidectomy by nasal endoscoPy under general anesthesia were selected and divided into the PreemPtive analgesia grouP ( T ) and the control grouP ( P ) randomly and e-qually. The grouP T was intravenously driPPed with tramadol 2 mg/kg before anesthetic induction, while the grouP P with 0. 9% sodium chloride solution 5mL before anesthetic induction. The two grouPs were Performed the oPeration by the target controlled infusion ( TCI ) of remifentanil hydrochloride combined low concentration isoflurane inhalation anesthesia. All children Patients were sent into PACU after extubation and from this time Point the visual analog scale ( VAS ) scores, Ramsay sedation score, PostoPerative nausea and vomiting ( PONV ) , and adverse reactions at the timePoints of 0, 2, 4, 6, 12, 24 h were recorded. Results The VAS and Ramsay sedation scores at the timePoints of 0-6 h in the grouP T were suPerior to those in the grouP P ( P<0. 05 ) . There were no significant differences in the VAS and Ramsay sedation scores at the timePoints of 12-24 h between the two grouPs ( P>0. 05 ) . No severe adverse reactions were found in both the two grouPs. Conclusion Tramadol can Provide effective and safe PreemPtive analgesia in Pediatric adenoidectomy by nasal endoscoPy.
