海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
12期
1787-1789,1790
,共4页
李肖然(综述)%鲁晓擘(审校)
李肖然(綜述)%魯曉擘(審校)
리초연(종술)%로효벽(심교)
TOLL样受体4%卡波西肉瘤%卡波西肉瘤相关疱疹病毒
TOLL樣受體4%卡波西肉瘤%卡波西肉瘤相關皰疹病毒
TOLL양수체4%잡파서육류%잡파서육류상관포진병독
Toll-like receptor 4 (TLR4)%Kaposi's sarcoma%Kaposi's sarcoma associated herpesvirus (KSHV)
TLR4(Toll-like receptor 4)是Toll样受体的一个重要的组成成员,是革兰氏阴性细胞壁成份脂多糖(LPS)的识别受体。活化TLR4将诱导产生一系列炎症介质,包括细胞因子、趋化因子等从而产生强有力的炎症反应,TLR4在抗细菌,抗病毒的炎症反应中,以及在应激状态下均发挥重要作用。TLR4在KSHV (Kaposi's sarcoma-associated herpesvirus,卡波西肉瘤相关疱疹病毒)感染的卡波西肉瘤中也有表达,本文就TLR4在KSHV感染的卡波西肉瘤中的信号转导机制及研究进展做一综述。
TLR4(Toll-like receptor 4)是Toll樣受體的一箇重要的組成成員,是革蘭氏陰性細胞壁成份脂多糖(LPS)的識彆受體。活化TLR4將誘導產生一繫列炎癥介質,包括細胞因子、趨化因子等從而產生彊有力的炎癥反應,TLR4在抗細菌,抗病毒的炎癥反應中,以及在應激狀態下均髮揮重要作用。TLR4在KSHV (Kaposi's sarcoma-associated herpesvirus,卡波西肉瘤相關皰疹病毒)感染的卡波西肉瘤中也有錶達,本文就TLR4在KSHV感染的卡波西肉瘤中的信號轉導機製及研究進展做一綜述。
TLR4(Toll-like receptor 4)시Toll양수체적일개중요적조성성원,시혁란씨음성세포벽성빈지다당(LPS)적식별수체。활화TLR4장유도산생일계렬염증개질,포괄세포인자、추화인자등종이산생강유력적염증반응,TLR4재항세균,항병독적염증반응중,이급재응격상태하균발휘중요작용。TLR4재KSHV (Kaposi's sarcoma-associated herpesvirus,잡파서육류상관포진병독)감염적잡파서육류중야유표체,본문취TLR4재KSHV감염적잡파서육류중적신호전도궤제급연구진전주일종술。
Toll-like receptor 4 (TLR4) is one of the important members of Toll like receptors, which is a rec-ognition receptor of lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria. Activation of TLR4 induced a series of inflammatory mediators, including cytokines and chemokines, to produce a strong inflammatory re-action. TLR4 played an important role in anti-bacteria, inflammation, antiviral, and stress. TLR4 was also expressed in kaposi's sarcoma, which is infected by Kaposi's sarcoma associated herpesvirus (KSHV). This paper reviewed the most recent advancements of signal transduction mechanism of TLR4 in Kaposi's sarcoma.