CAJ | 학술논문

目的：探讨血必净注射液对脓毒症合并急性肾损伤(AKI)患者的肾功能及血清IL-6、TNF-α的影响。方法38例脓毒症合并AKI患者随机分为两组，对照组予常规治疗，观察组在此基础上联合应用血必净注射液，比较治疗前后肾功能及血清IL-6、TNF-α的变化及需要血液净化治疗的比例和死亡率的差异。结果治疗7 d后，观察组肾功能指标Scr、BUN及炎症指标IL-6、TNF-α水平均明显低于对照组，差异有统计学意义(P<0.05)；观察组接受血液净化治疗的比例为21.05%，明显低于对照组的47.37%，差异有统计学意义(P<0.05)；两组患者死亡率比较差异无统计学意义(P>0.05)。结论血必净注射液可降低脓毒症AKI患者血清IL-6、TNF-α的水平，改善患者肾功能指标，对肾功能具有明显的保护作用。
목적：탐토혈필정주사액대농독증합병급성신손상(AKI)환자적신공능급혈청IL-6、TNF-α적영향。방법38례농독증합병AKI환자수궤분위량조，대조조여상규치료，관찰조재차기출상연합응용혈필정주사액，비교치료전후신공능급혈청IL-6、TNF-α적변화급수요혈액정화치료적비례화사망솔적차이。결과치료7 d후，관찰조신공능지표Scr、BUN급염증지표IL-6、TNF-α수평균명현저우대조조，차이유통계학의의(P<0.05)；관찰조접수혈액정화치료적비례위21.05%，명현저우대조조적47.37%，차이유통계학의의(P<0.05)；량조환자사망솔비교차이무통계학의의(P>0.05)。결론혈필정주사액가강저농독증AKI환자혈청IL-6、TNF-α적수평，개선환자신공능지표，대신공능구유명현적보호작용。
Objective To investigate the impact of Xuebijing injection on renal function and serum IL-6 and TNF-αin patients with sepsis and acute kidney injury. Methods Thirty-eight patients with sepsis and AKI were ran-domly divided into two groups. The control group received conventional treatment, and the observation group re-ceived added Xuebijing injection. Renal function and serum IL-6 and TNF-αwere compared as well as the proportion of blood purification treatment and mortality. Results After 7days treatment, the levels of renal function (Scr and BUN) and inflammatory markers (IL-6 and TNF-α) in observation group were significantly lower than those in the control group (P<0.05). The proportion of blood purification treatment in observation group was 21.05%, which was significantly lower than that in the control group as 47.37% (P<0.05). The mortality difference between the two groups were not of statistically significant (P>0.05). Conclusion Xuebijing injection can reduce serum IL-6 and TNF-αlevels in patients with septic and AKI, and improve renal function. It has a significant protective effect on re-nal function.