CAJ | 학술논문

目的：探究联合检测C-反应蛋白(CRP)和胱抑素C (Cys C)对痛风患者早期肾损伤的诊断价值。方法选取2010年6月至2013年6月我院收治的260例痛风患者，按照是否伴有早期肾损伤分为A组(伴有早期肾损伤组)B组(未伴有早期损伤组)各130例，检测与对比两组患者的CRP与Cys C水平。结果 A组CRP、Cys C水平均显著高于B组，肾小球滤过率显著低于B组，差异具有统计学意义(P<0.05)；A组患者的CRP与Cys C联合检测的阳性率均显著高于CRP单独检测阳性率与Cys C单独检测阳性率，差异具有统计学意义(P<0.05)，而CRP与Cys C阳性率对比，差异不具有统计学意义(P>0.05)；CRP与Cys C联合检测的敏感度与特异度分别为88.9%与84.9%。结论对痛风患者进行CRP与Cys C联合检测，能够有效提高早期肾损伤的阳性检出率，增加诊断可靠性，具有临床推广价值。
목적：탐구연합검측C-반응단백(CRP)화광억소C (Cys C)대통풍환자조기신손상적진단개치。방법선취2010년6월지2013년6월아원수치적260례통풍환자，안조시부반유조기신손상분위A조(반유조기신손상조)B조(미반유조기손상조)각130례，검측여대비량조환자적CRP여Cys C수평。결과 A조CRP、Cys C수평균현저고우B조，신소구려과솔현저저우B조，차이구유통계학의의(P<0.05)；A조환자적CRP여Cys C연합검측적양성솔균현저고우CRP단독검측양성솔여Cys C단독검측양성솔，차이구유통계학의의(P<0.05)，이CRP여Cys C양성솔대비，차이불구유통계학의의(P>0.05)；CRP여Cys C연합검측적민감도여특이도분별위88.9%여84.9%。결론대통풍환자진행CRP여Cys C연합검측，능구유효제고조기신손상적양성검출솔，증가진단가고성，구유림상추엄개치。
Objective To explore the the diagnostic significance of combined detection of serum C reactive protein (CRP) and cystatin C (Cys C) for early renal injury in gouty patients. Methods 260 cases of gouty patients were divided into 2 groups:group A (with early renal damage group, n=130), group B (without early renal damage group, n=130), the serum CRP and Cys C from two groups were measured and compared respectively. Results The levels of CRP and Cys C in group A were significantly higher than those group B (P<0.05). The positive rate of CRP and Cys C combined detection in group A was significantly higher than those in group B (P<0.05). Comparing the pos-itive ratio of CRP or Cys C in two groups respectively,there were no obvious difference in statistic (P>0.05). The sensitivity rate and specificity rate of combination detection of CRP and Cys C were 88.9%and 84.9%respectively. Conclusion Simultaneous determination of serum CRP and Cys C can help to assess the early renal injury in pa-tients with gout, and increase the diagnostic reliability,which is worthy of clinical application.