CAJ | 학술논문

目前对海洋抗肿瘤药物的研究已经成为全世界普遍关注的热点，海洋天然产物现已成为临床抗癌药物的重要来源。Ecteinascidin-743是从加勒比海海鞘Ecteinascidia turbinata中分离提取得到的海洋生物碱，抗肿瘤活性明显高于目前临床上广泛使用的抗肿瘤药物，对多种肿瘤细胞如白血病、卵巢癌、软组织肉瘤、黑素瘤、宫颈癌、乳腺癌、结直肠癌、肾癌、前列腺癌、肺癌及非小细胞肺癌等有明显抑制活性，是首个成功应用到临床的海洋抗肿瘤药物。本文检索近年相关文献，对该药的合成、药理及临床研究进展作一综述。
목전대해양항종류약물적연구이경성위전세계보편관주적열점，해양천연산물현이성위림상항암약물적중요래원。Ecteinascidin-743시종가륵비해해초Ecteinascidia turbinata중분리제취득도적해양생물감，항종류활성명현고우목전림상상엄범사용적항종류약물，대다충종류세포여백혈병、란소암、연조직육류、흑소류、궁경암、유선암、결직장암、신암、전렬선암、폐암급비소세포폐암등유명현억제활성，시수개성공응용도림상적해양항종류약물。본문검색근년상관문헌，대해약적합성、약리급림상연구진전작일종술。
At present the study of Marine antineoplastic drugs has already become the focus of concern around the world, Marine natural products has become an important source of clinical anti-cancer drugs. Ecteinascidin-743 from the Caribbean sea squirts Ecteinascidia turbinata extraction have been the ocean alkaloid, antitumor activity is significantly higher than the current widely used clinical antitumor drugs, inhibit a wide variety of tumor cell activity such as leukemia, ovarian cancer, soft tissue sarcoma, melanoma, cervical cancer, breast cancer, colorectal cancer, kidney cancer, prostate cancer, lung cancer and non-small cell lung cancer and other tumor cells, is the first successful application to the oceans, clinical antitumor drugs. In this paper, the drug synthesis, pharmacological and clinical research progress were reviewed.