CAJ | 학술논문

目的：对两种方案治疗急性缺血性脑血管病进行药物经济学评价。方法将212例缺血性急性脑血管病中符合方案分析集的206例患者，随机分为2组，序贯治疗A组102例，用脑苷肌肽注射液18 mL加入5%葡萄糖注射液250 ml中，ivgtt，qd；7 d后改用丁苯酞软胶囊，0.2 g，qid，po；联合消栓通络胶囊2.1 g，tid，po至14 d。对照B组104例，采用脑苷肌肽注射液18 ml加入5%葡萄糖注射液250 mL中，ivgtt，qd，至14 d。两组基础治疗相同。治疗结束后对2组患者进行神经功能缺损评分（ESS）和日常生活能力评分（ADL）同时进行临床疗效及安全性比较。运用药物经济学的成本-效果分析法进行分析。结果2组临床总有效率和不良反应发生率分别为92.2%、95.2%和4.7％、7.5％，以临床总有效率计C/E分别为129.1和178.5；ΔC/ΔE为1697.7。结论2组临床疗效相近但治疗成本有显著性差异，序贯治疗组治疗急性缺血性脑血管病更具有成本-效果优势。
목적：대량충방안치료급성결혈성뇌혈관병진행약물경제학평개。방법장212례결혈성급성뇌혈관병중부합방안분석집적206례환자，수궤분위2조，서관치료A조102례，용뇌감기태주사액18 mL가입5%포도당주사액250 ml중，ivgtt，qd；7 d후개용정분태연효낭，0.2 g，qid，po；연합소전통락효낭2.1 g，tid，po지14 d。대조B조104례，채용뇌감기태주사액18 ml가입5%포도당주사액250 mL중，ivgtt，qd，지14 d。량조기출치료상동。치료결속후대2조환자진행신경공능결손평분（ESS）화일상생활능력평분（ADL）동시진행림상료효급안전성비교。운용약물경제학적성본-효과분석법진행분석。결과2조림상총유효솔화불량반응발생솔분별위92.2%、95.2%화4.7％、7.5％，이림상총유효솔계C/E분별위129.1화178.5；ΔC/ΔE위1697.7。결론2조림상료효상근단치료성본유현저성차이，서관치료조치료급성결혈성뇌혈관병경구유성본-효과우세。
Objective To estimate the pharmacoeconomics of two remedy scheme in curing acute cerebral infarction. Method In 212 cases with acute cerebral infarction patients, 206 cases were adopted, and randomly divided into two group. Group A was 102 cases and Group B was 104 cases. Group A was administered with 18 ml cattle encephalon glycoside which was added into 250 ml 5%glucose injection, ivgtt, qd. After 7 days it was administered compound Butylphthalide Soft Capsules, 0.2 g qid, combined Xiaoshuantongluo capsule, 2.1 g tid until 14 days later. Group B was administered with cattle encephalon glycoside and ignotin injection 18 ml which was added into 250 ml 5%glucose injection, ivgtt, qd until 14 days. The basic therapy of two groups were same. After therapy compared the safety and clinic curative effect from European Stroke Scale(ESS) and activities of daily living(ADL).Then outcome-effectiveness was assayed in pharmacoeconomics. Results The total effective rate were 92.2 and 95.2%,and ccurrence of adverse react were 4.7 and 7.5, respectively,in the two group.The clinic total effective rate counting C/E was respectively 129.1 and 178.5;ΔC/ΔE was 1697.7. Conclusion The clinic curative effect of two group was intimate, but the cost had signiifcant difference. The sequential antimicrobial therapy in curing acute cerebral infarction had excellent advantage in outcome-effectiveness.