中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
1期
130-131,134
,共3页
清热利湿解毒%老年系统性红斑狼疮%副作用
清熱利濕解毒%老年繫統性紅斑狼瘡%副作用
청열리습해독%노년계통성홍반랑창%부작용
clearing heat and removing dampness detoxiifcation%the old systemic lupus erythema tosus%side effect
目的：对清热利湿解毒方剂在老年SLE副作用中的治疗效果进行评价。方法随机选取我院在2011年4月-2013年6月接收治疗的68例老年SLE患者，并将其平均分成对照组和观察组两组，每组34例，其中对照组患者单纯的采用激素进行治疗，观察组患者则在此基础上，加上中医清热利湿解毒方剂进行治疗。最后对两组患者的临床治疗效果和药物副作用进行对比分析。结果观察组患者的临床治疗总有效率为91.2%，高于对照组的70.6%，其差异显著，比较具有统计学意义（P＜0.05）；两组患者经过治疗后，其SLEDAI积分均有所下降，其中观察组患者治疗后的SLEDAI积分显著低于对照组（P＜0.05）；观察组患者的药物副作用发生率为14.7%，对照组患者则为52.9%，差异显著（P＜0.05）。结论在老年SLE治疗中采用清热利湿解毒方剂，不但可以对其临床治疗有效性进行提高，还可以有效的减少药物副作用的出现，提高患者的生存质量，值得在临床中推广使用。
目的：對清熱利濕解毒方劑在老年SLE副作用中的治療效果進行評價。方法隨機選取我院在2011年4月-2013年6月接收治療的68例老年SLE患者，併將其平均分成對照組和觀察組兩組，每組34例，其中對照組患者單純的採用激素進行治療，觀察組患者則在此基礎上，加上中醫清熱利濕解毒方劑進行治療。最後對兩組患者的臨床治療效果和藥物副作用進行對比分析。結果觀察組患者的臨床治療總有效率為91.2%，高于對照組的70.6%，其差異顯著，比較具有統計學意義（P＜0.05）；兩組患者經過治療後，其SLEDAI積分均有所下降，其中觀察組患者治療後的SLEDAI積分顯著低于對照組（P＜0.05）；觀察組患者的藥物副作用髮生率為14.7%，對照組患者則為52.9%，差異顯著（P＜0.05）。結論在老年SLE治療中採用清熱利濕解毒方劑，不但可以對其臨床治療有效性進行提高，還可以有效的減少藥物副作用的齣現，提高患者的生存質量，值得在臨床中推廣使用。
목적：대청열리습해독방제재노년SLE부작용중적치료효과진행평개。방법수궤선취아원재2011년4월-2013년6월접수치료적68례노년SLE환자，병장기평균분성대조조화관찰조량조，매조34례，기중대조조환자단순적채용격소진행치료，관찰조환자칙재차기출상，가상중의청열리습해독방제진행치료。최후대량조환자적림상치료효과화약물부작용진행대비분석。결과관찰조환자적림상치료총유효솔위91.2%，고우대조조적70.6%，기차이현저，비교구유통계학의의（P＜0.05）；량조환자경과치료후，기SLEDAI적분균유소하강，기중관찰조환자치료후적SLEDAI적분현저저우대조조（P＜0.05）；관찰조환자적약물부작용발생솔위14.7%，대조조환자칙위52.9%，차이현저（P＜0.05）。결론재노년SLE치료중채용청열리습해독방제，불단가이대기림상치료유효성진행제고，환가이유효적감소약물부작용적출현，제고환자적생존질량，치득재림상중추엄사용。
Objective To evaluate the therapeutic effect of clearing heat and removing dampness detoxiifcation prescription in the elderly SLE of side effects. Method 68 cases of elderly patients with SLE receiving treatment in our hospital in 2011 April-2013 year in June were randomly divided into observation group and control group, 34 cases in each group. Patients in control group only use hormone therapy, while patients in observation group were added traditional chinese medicine prescription for clearing heat and wet detoxiifcation treatment on basis of this. Finally, the clinical therapeutic effect of two groups and side effects of the drug were analyzed. Results The total effective rate of clinical observation in treatment group was 91.2%, which higher than that of the control group ,and the difference was signiifcant (P<0.05). Compared with control group, the SLEDAI score in observation group was signiifcantly lower, and the difference was signiifcant (P<0.05);drug side effects in observation group was 14.7%, while that in control group was 52.9%, the difference between them was signiifcant (P<0.05). Conclusion Using clearing heat and removing dampness detoxification prescription in elderly patients with SLE treatment, not only can the clinical therapeutic effectiveness of improving, but also can effectively reduce the appearance of drug side effects, improve the life quality of patients, it is worth to promotion in clinical use.
