中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
1期
118-120
,共3页
寇光%尹绢%邱元芝%汤韶明
寇光%尹絹%邱元芝%湯韶明
구광%윤견%구원지%탕소명
中药补肾调周法%石英毓麟汤%多囊卵巢综合征%瘦素
中藥補腎調週法%石英毓麟湯%多囊卵巢綜閤徵%瘦素
중약보신조주법%석영육린탕%다낭란소종합정%수소
tonifying kidney with traditional Chinese medicine%Shiying Minlin soup%polycystic ovarian syndrome%leptin
目的：探讨石英毓麟汤补肾调周法配合戊酸雌二醇片和氯菧酚胺治疗多囊卵巢综合征(polycystic ovarian syndrome，PCOS)的疗效及对患者血清瘦素的影响。方法208例PCOS患者随机分为观察组104例和对照组104例。对照组服用雌二醇片和氯菧酚胺，观察组在对照组的基础上加服石英毓麟汤补，累计3个周期；对患者的多毛，测定基础体温，座疮和月经异常情况进行了记录；采用酶联免疫法检测血清瘦素(leptin,LP)和促卵泡生成激素（follicle stimulating hormone,FSH），促黄体生成激素(luteinizing hormone,LH)，泌乳素(prolactin,PRL)，雌二醇(estradiol,E 2)，睾酮(testosterone,T)五种内分泌激素含量。结果采用西药和中药补肾调周法治疗后的患者月经异常﹑痤疮﹑多毛﹑单相测定基础体温情况比治疗前明显改善；两组患者的FSH,LH,PRL,E 2，T均有所降低，而观察组患者的FSH和PRL均高于对照组，LH，T和E2水平均低于对照组。结论中药补肾调周法治疗PCOS能显著降低FSH,LH,PRL,E 2，T和LP水平。相较于单纯使用西药，中药补肾调周法优于单纯使用西药治疗。
目的：探討石英毓麟湯補腎調週法配閤戊痠雌二醇片和氯菧酚胺治療多囊卵巢綜閤徵(polycystic ovarian syndrome，PCOS)的療效及對患者血清瘦素的影響。方法208例PCOS患者隨機分為觀察組104例和對照組104例。對照組服用雌二醇片和氯菧酚胺，觀察組在對照組的基礎上加服石英毓麟湯補，纍計3箇週期；對患者的多毛，測定基礎體溫，座瘡和月經異常情況進行瞭記錄；採用酶聯免疫法檢測血清瘦素(leptin,LP)和促卵泡生成激素（follicle stimulating hormone,FSH），促黃體生成激素(luteinizing hormone,LH)，泌乳素(prolactin,PRL)，雌二醇(estradiol,E 2)，睪酮(testosterone,T)五種內分泌激素含量。結果採用西藥和中藥補腎調週法治療後的患者月經異常﹑痤瘡﹑多毛﹑單相測定基礎體溫情況比治療前明顯改善；兩組患者的FSH,LH,PRL,E 2，T均有所降低，而觀察組患者的FSH和PRL均高于對照組，LH，T和E2水平均低于對照組。結論中藥補腎調週法治療PCOS能顯著降低FSH,LH,PRL,E 2，T和LP水平。相較于單純使用西藥，中藥補腎調週法優于單純使用西藥治療。
목적：탐토석영육린탕보신조주법배합무산자이순편화록저분알치료다낭란소종합정(polycystic ovarian syndrome，PCOS)적료효급대환자혈청수소적영향。방법208례PCOS환자수궤분위관찰조104례화대조조104례。대조조복용자이순편화록저분알，관찰조재대조조적기출상가복석영육린탕보，루계3개주기；대환자적다모，측정기출체온，좌창화월경이상정황진행료기록；채용매련면역법검측혈청수소(leptin,LP)화촉란포생성격소（follicle stimulating hormone,FSH），촉황체생성격소(luteinizing hormone,LH)，비유소(prolactin,PRL)，자이순(estradiol,E 2)，고동(testosterone,T)오충내분비격소함량。결과채용서약화중약보신조주법치료후적환자월경이상﹑좌창﹑다모﹑단상측정기출체온정황비치료전명현개선；량조환자적FSH,LH,PRL,E 2，T균유소강저，이관찰조환자적FSH화PRL균고우대조조，LH，T화E2수평균저우대조조。결론중약보신조주법치료PCOS능현저강저FSH,LH,PRL,E 2，T화LP수평。상교우단순사용서약，중약보신조주법우우단순사용서약치료。
Objective To explore the effect of tonifying kidney with traditional Chinese medicine together with estradiol valerate and clomiphene citrate on serum leptin levels in patients with polycystic ovarian syndrome. Method Two hundred and eight patients with PCOS were randomly divided into observation group (n=104) and control group (n=104). Patients in control group and observation group took estradiol valerate and clomiphene citrate, while patients in observation group took Shiying Minlin soup for three months. Crinosity, body temperature, acne&Skin diseases, and menoxenia were recorded; Leptin (LP) and five hormone including follicle stimulating hormone (FSH),luteinizing hormone (LH), prolactin (PRL), estradiol (E 2) and testosterone (T) are determined using euzymelinked immunosorbent assay. Results Crinosity, body temperature, acne&Skin diseases, and menoxenia were improved;the level of FSH, LH, PRL, E 2, T in both observation and control group decreased and the content in observation group are high than that in control group, while LH,T and E 2 are lower. Conclusion Treatment with tonifying kidney with traditional Chinese medicine on polycystic ovarian syndrome can decrease the level of FSH, LH, PRL, E 2, T and LP. Compared with western medicine, tonifying kidney with traditional Chinese medicine showed advantage in the terms of treatment on polycystic ovarian syndrome.
