CAJ | 학술논문

目的：本研究采用回顾性分析不同剂量甲氨蝶呤在儿童急性淋巴细胞白血病治疗中的毒副反应。方法将28例完全缓解期的急性淋巴细胞白血病患儿随机分为2组，A组16例应用甲氨蝶呤3.0 g/m2治疗，B组12例应用甲氨蝶呤5.0 g/m 2，比较2组不良反应。结果甲氨蝶呤常见的毒副反应为骨髓抑制、口腔黏膜溃疡、胃肠道反应及肝功能损害等，多为轻度。2组毒副反应发生率比较差异无统计学意义。结论甲氨蝶呤治疗儿童急性淋巴细胞白血病时，不良反应较常见，但大多可耐受。
목적：본연구채용회고성분석불동제량갑안접령재인동급성림파세포백혈병치료중적독부반응。방법장28례완전완해기적급성림파세포백혈병환인수궤분위2조，A조16례응용갑안접령3.0 g/m2치료，B조12례응용갑안접령5.0 g/m 2，비교2조불량반응。결과갑안접령상견적독부반응위골수억제、구강점막궤양、위장도반응급간공능손해등，다위경도。2조독부반응발생솔비교차이무통계학의의。결론갑안접령치료인동급성림파세포백혈병시，불량반응교상견，단대다가내수。
Objective To investigate the toxicities of methotrexate in the treatment of the children with acute lymphoblastic leukemia Method 28 children with acute lymphoblastic leukemia were randomly divided into two groups(A and B), they were treated with methotrexate 3.0 g/m 2 (n=16) and 5.0 g/m 2(n=12). The toxicities of two doses of methotrexate were observed. Results The main toxicities of methotrexate were marrow suppression,gastrointestinal reaction and liver damage. They were mostly mild.No statistically significant difference was found between group A and group B .Conclusion The toxicities of methotrexate are common and can be tolerated.