中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
1期
100-101,103
,共3页
急性胆囊炎%生长抑素%C反应蛋白%前白蛋白
急性膽囊炎%生長抑素%C反應蛋白%前白蛋白
급성담낭염%생장억소%C반응단백%전백단백
acute cholecystitis%somatostatin%C-reactive protein%prealbumin
目的：观察生长抑素对老年急性化脓性胆囊炎的疗效及其对术前术后机体C反应蛋白（C-reactive protein,CRP）、前白蛋白（preal bumin,PA）和总胆红素（total bilirubin,TBIL）的影响。方法选取2011年1月～2013年6月在上海市第一人民医院宝山分院就诊治疗的急性化脓性胆囊炎患者110例，随机分为观察组和对照组，每组55例。对照组予以手术治疗，观察组在对照组的基础上术前术后予以生长抑素治疗。观察2组手术时间、术中出血量、术后视觉模拟评分法（visual analog scale，VAS）评分和并发症发生率的情况；及两组治疗前后CRP、PA和TBIL水平的变化。结果治疗后，观察组的术中出血量，术后住院时间和术后并发症发生率明显低于对照组（P<0.01），而手术时间和术后VAS评分差异无统计学意义。2组治疗后，CRP和TBIL水平较治疗前出现显著降低（P<0.01），而PA水平较治疗前出现显著升高（P<0.01），观察组的降低或者升高水平较对照组更为明显（P<0.01）。结论生长抑素对急性化脓性胆囊炎术前术后的辅助治疗疗效确切，可明显降低机体的炎症反应，促进患者术后的康复。
目的：觀察生長抑素對老年急性化膿性膽囊炎的療效及其對術前術後機體C反應蛋白（C-reactive protein,CRP）、前白蛋白（preal bumin,PA）和總膽紅素（total bilirubin,TBIL）的影響。方法選取2011年1月～2013年6月在上海市第一人民醫院寶山分院就診治療的急性化膿性膽囊炎患者110例，隨機分為觀察組和對照組，每組55例。對照組予以手術治療，觀察組在對照組的基礎上術前術後予以生長抑素治療。觀察2組手術時間、術中齣血量、術後視覺模擬評分法（visual analog scale，VAS）評分和併髮癥髮生率的情況；及兩組治療前後CRP、PA和TBIL水平的變化。結果治療後，觀察組的術中齣血量，術後住院時間和術後併髮癥髮生率明顯低于對照組（P<0.01），而手術時間和術後VAS評分差異無統計學意義。2組治療後，CRP和TBIL水平較治療前齣現顯著降低（P<0.01），而PA水平較治療前齣現顯著升高（P<0.01），觀察組的降低或者升高水平較對照組更為明顯（P<0.01）。結論生長抑素對急性化膿性膽囊炎術前術後的輔助治療療效確切，可明顯降低機體的炎癥反應，促進患者術後的康複。
목적：관찰생장억소대노년급성화농성담낭염적료효급기대술전술후궤체C반응단백（C-reactive protein,CRP）、전백단백（preal bumin,PA）화총담홍소（total bilirubin,TBIL）적영향。방법선취2011년1월～2013년6월재상해시제일인민의원보산분원취진치료적급성화농성담낭염환자110례，수궤분위관찰조화대조조，매조55례。대조조여이수술치료，관찰조재대조조적기출상술전술후여이생장억소치료。관찰2조수술시간、술중출혈량、술후시각모의평분법（visual analog scale，VAS）평분화병발증발생솔적정황；급량조치료전후CRP、PA화TBIL수평적변화。결과치료후，관찰조적술중출혈량，술후주원시간화술후병발증발생솔명현저우대조조（P<0.01），이수술시간화술후VAS평분차이무통계학의의。2조치료후，CRP화TBIL수평교치료전출현현저강저（P<0.01），이PA수평교치료전출현현저승고（P<0.01），관찰조적강저혹자승고수평교대조조경위명현（P<0.01）。결론생장억소대급성화농성담낭염술전술후적보조치료료효학절，가명현강저궤체적염증반응，촉진환자술후적강복。
Objective To observe the efficacy of somatostatin on elderly patients with acute suppurative cholecystitis and its impact on the C-reactive protein (CRP), prealbumin (PA) and total bilirubin (TBIL) effects before or after operation. Method 110 elderly patients with acute suppurative cholecystitis, which from January 2011 to June 2013, were randomly divided into observation group and control group, each group had 55 cases, the control group were gave operation, the observation group were treated with somatostatin on basis of control group before and after operation. The operative time, blood loss, postoperative visual analog scale (VAS) score and morbidity were observed. At the same time, the levels of CRP, PA and TBIL were detected before and after operation. Results After treatment, the blood loss, postoperative hospital stay and postoperative complication rate in observation group were significantly lower than those in control group (P<0.01), while the differences in operative time and postoperative VAS score between two groups were not significant . After treatment, the levels of CRP, and TBIL appear significantly lower than those before treatment (P<0.01), while the PA levels appear significantly higher compared with those before treatment (P<0.01), the decreasing or increasing levels in observation group were more obvious compared with control group (P<0.01). Conclusion The adjuvant therapy efficacy of somatostatin were obvious before and after operation, they can significantly reduce the body's inflammatory response, and promote the postoperative recovery.
