CAJ | 학술논문

目的：探讨胺碘酮联合索他洛尔救治快速室上性心律失常的临床疗效。方法：选取2010年8月至2013年10月广州市荔湾区第二人民医院收治的128例快速室上性心律失常患者作为研究对象，随机分为对照组(胺碘酮)和观察组(胺碘酮＋索他洛尔)，每组各64例。观察两组患者的临床疗效及药物起效时间、治疗后心率、窦性心律复转率等指标。结果：观察组有效率为94％(60/64)，高于对照组的80％(51/64)；观察组药物起效时间及治疗后心率均显著低于对照组；窦性心律复转率明显高于对照组；上述指标比较，差异均有统计学意义( P<0.05)。结论：胺碘酮联合索他洛尔治疗快速室上性心律失常起效快、效果好。
목적：탐토알전동연합색타락이구치쾌속실상성심률실상적림상료효。방법：선취2010년8월지2013년10월엄주시려만구제이인민의원수치적128례쾌속실상성심률실상환자작위연구대상，수궤분위대조조(알전동)화관찰조(알전동＋색타락이)，매조각64례。관찰량조환자적림상료효급약물기효시간、치료후심솔、두성심률복전솔등지표。결과：관찰조유효솔위94％(60/64)，고우대조조적80％(51/64)；관찰조약물기효시간급치료후심솔균현저저우대조조；두성심률복전솔명현고우대조조；상술지표비교，차이균유통계학의의( P<0.05)。결론：알전동연합색타락이치료쾌속실상성심률실상기효쾌、효과호。
Objective:To investigate the clinical utility of amiodarone combined with sotalol for rapid supraventricular arrhythmia ( RSA ) . Methods: Between August 2010 and October 2013, we recruited 128 patients with RSA from Second People’ s Hospital of Liwan District, Guangzhou. Patients were randomly assigned to be treated with oral amiodarone therapy alone ( control group, n=64) or in combination with sotalol ( treatment group, n=64) . The efficacy in terms of time of onset, post treatment heart rate and, the rate of sinus complex transfer were assessed. Results:The effective rate was higher in treatment group (93.75% (60/64) vs. 79.69%(51/64)) than control group (P<0.05). The treatment group was associated with a shorter time of onset, a lower level of heart rate and higher rate of sinus rhythm ( all P<0.05) . Conclusion:Amiodarone combined with sotalol is characterized by an ideal efficacy in patients with RSA.