CAJ | 학술논문

目的：探讨地方性砷中毒尤其是饮水型砷暴露与肝损伤是否有相关性。方法检索纳入了国内外有关地方性砷中毒中砷暴露与肝损伤的文献6篇，采用M eta分析的方法，应用固定效应模型和随机效应模型进行综合的定量分析，计算合并OR值及95％可信区间，利用漏斗图法定性评价发表偏倚。结果异质性检验χ2＝8．01，P＝0.16，采用固定效应模型进行M eta分析，合并OR＝3．72，95％ C I为3．08～4．49，表明M eta分析砷暴露组的肝损害发病可能性高于对照组。结论地方性砷中毒病区的砷暴露可能会引起暴露人群的肝脏疾病损伤高发，长期砷暴露会对当地居民的肝功能或器质性损伤存在一定程度的不良影响。
목적：탐토지방성신중독우기시음수형신폭로여간손상시부유상관성。방법검색납입료국내외유관지방성신중독중신폭로여간손상적문헌6편，채용M eta분석적방법，응용고정효응모형화수궤효응모형진행종합적정량분석，계산합병OR치급95％가신구간，이용루두도법정성평개발표편의。결과이질성검험χ2＝8．01，P＝0.16，채용고정효응모형진행M eta분석，합병OR＝3．72，95％ C I위3．08～4．49，표명M eta분석신폭로조적간손해발병가능성고우대조조。결론지방성신중독병구적신폭로가능회인기폭로인군적간장질병손상고발，장기신폭로회대당지거민적간공능혹기질성손상존재일정정도적불량영향。
Objective To investigate whether there is correlation between the endemic arsenic poisoning and liver injury ,especially drinking water arsenic exposure .Methods Use Meta-analysis methods analyse 6 literatures which were retrieved about the arsenic exposure with liver injury in domestic and foreign endemic arsenic poisoning . Use fixed effects model and random effects model for comprehensive quantitative analysis and calculate pooled OR and OR values 95% confidence interval .The funnel plot statutory apply to assess the publication bias .Results Het-erogeneity test χ2 =8 .01 ,P=0 .16 ;fixed effects model Meta-analysis revealed the combined OR=3 .72 (95% CI 3.08~4 .49);Meta-analysis showed that arsenic exposure group having higher possibility incidence of liver damage than the control group .Conclusion Arsenic exposure in the endemic arsenic poisoning area may cause high inci-dence of liver disease to exposed populations ,long-term arsenic exposure to local residents also caused damage to liv-er function and physical .