CAJ | 학술논문

自从1957年Smithies等发现转铁蛋白（Tf）变异型后，许多学者对 Tf进行了广泛的研究。Tf作为一种重要的血清遗传标志，已经成为人类学、群体遗传学、法医学及临床医学等领域的重要研究内容。近年来 Tf遗传多态性与疾病相关性也引起了人们的重视。本文拟对转铁蛋白的结构、理化性质、生理功能、多态性、检测方法及其医学应用加以阐述。
자종1957년Smithies등발현전철단백（Tf）변이형후，허다학자대 Tf진행료엄범적연구。Tf작위일충중요적혈청유전표지，이경성위인류학、군체유전학、법의학급림상의학등영역적중요연구내용。근년래 Tf유전다태성여질병상관성야인기료인문적중시。본문의대전철단백적결구、이화성질、생리공능、다태성、검측방법급기의학응용가이천술。
Since Smithies et al .found transferring (Tf) variants in 1957 ,many scholars have conducted extensive research on Tf .Tf of serum as an important genetic markers has become important research target in anthropology , population genetics ,forensic and clinical medicine .In recent years ,the relations between Tf genetic polymorphism and the disease attracted great attention .The transferrin protein structure ,physical properties ,physiological func-tion ,detection methods ,polymorphism and its medical applications were reviewed in the paper .