国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
9期
1188-1190
,共3页
佐米曲普坦%温敏凝胶%鼻腔给药%黏膜渗透
佐米麯普坦%溫敏凝膠%鼻腔給藥%黏膜滲透
좌미곡보탄%온민응효%비강급약%점막삼투
Zolmitriptan%Thermosensible gel%Nasal drug delivery%Mucosa permeability
目的 研制佐米曲普坦鼻用温敏凝胶并考察其体外黏膜渗透特点.方法 以泊洛沙姆P407为凝胶材料,以泊洛沙姆P188、PEG6000调节胶凝温度与时间,采用正交实验筛选处方,并进行体外鼻黏膜渗透试验.结果 佐米曲普坦温敏凝胶在33℃下,可迅速胶凝,并具有一定的黏膜渗透量.结论 佐米曲普坦温敏凝胶处方设计合理,可进一步深入研究.
目的 研製佐米麯普坦鼻用溫敏凝膠併攷察其體外黏膜滲透特點.方法 以泊洛沙姆P407為凝膠材料,以泊洛沙姆P188、PEG6000調節膠凝溫度與時間,採用正交實驗篩選處方,併進行體外鼻黏膜滲透試驗.結果 佐米麯普坦溫敏凝膠在33℃下,可迅速膠凝,併具有一定的黏膜滲透量.結論 佐米麯普坦溫敏凝膠處方設計閤理,可進一步深入研究.
목적 연제좌미곡보탄비용온민응효병고찰기체외점막삼투특점.방법 이박락사모P407위응효재료,이박락사모P188、PEG6000조절효응온도여시간,채용정교실험사선처방,병진행체외비점막삼투시험.결과 좌미곡보탄온민응효재33℃하,가신속효응,병구유일정적점막삼투량.결론 좌미곡보탄온민응효처방설계합리,가진일보심입연구.
Objective To develop Zolmitriptan nasal thermosensible gel and study its nasal mucosa permeability in vitro.Methods The gel was prepared by P407 as the main gel matrix with P188 and PEG6000 as regulators.The form ulation was screened by the orthogonal test and its permeability was proceeded in vitro.Results Zolmitriptannasal thermosensible gel was gelated quickly at 33℃ and the drug release remained constant.Conclusion The formulation of Zolmitriptan nasal thermosensible gel is reasonable and valuable for further research.
