CAJ | 학술논문

茶多酚、维生素E和硒都是较强的抗氧化剂,对多种疾病具有预防和治疗作用。试验选用50只昆明清洁级小鼠,采用不同剂量茶多酚维E硒胶囊连续灌胃30 d,通过测定小鼠受试前后体重、血清超氧化物歧化酶(SOD)活力及8Gy60Coγ射线造模前后肝组织丙二醛(MDA)含量、SOD和谷胱甘肽过氧化物酶(GSH-Px)活力,研究茶多酚维E硒胶囊对小鼠抗氧化系统的影响。结果显示,与模型对照组相比,各剂量茶多酚维E硒胶囊对造模后小鼠肝组织SOD活力无显著影响；75、150 mg/kg?bw茶多酚维E硒胶囊对造模后小鼠肝组织MDA含量和GSH-Px活力也无显著影响；300 mg/kg?bw茶多酚维E硒胶囊剂量组可显著降低造模后小鼠肝组织MDA含量,提高其GSH-Px活力。以上结果为茶多酚、维生素E和硒在食品及保健品中的联合应用提供了理论依据。
다다분、유생소E화서도시교강적항양화제,대다충질병구유예방화치료작용。시험선용50지곤명청길급소서,채용불동제량다다분유E서효낭련속관위30 d,통과측정소서수시전후체중、혈청초양화물기화매(SOD)활력급8Gy60Coγ사선조모전후간조직병이철(MDA)함량、SOD화곡광감태과양화물매(GSH-Px)활력,연구다다분유E서효낭대소서항양화계통적영향。결과현시,여모형대조조상비,각제량다다분유E서효낭대조모후소서간조직SOD활력무현저영향；75、150 mg/kg?bw다다분유E서효낭대조모후소서간조직MDA함량화GSH-Px활력야무현저영향；300 mg/kg?bw다다분유E서효낭제량조가현저강저조모후소서간조직MDA함량,제고기GSH-Px활력。이상결과위다다분、유생소E화서재식품급보건품중적연합응용제공료이론의거。
Tea polyphenol, VE and selenium are strong antioxidants, useful for prevention and therapy of many diseases. 50 CL Kunming mice were randomly allocated to 5 groups and treated with different dose of capsule with polyphenol, VE and selenium for 30 days. The indices for evaluating effects of the capsules on the antioxidant systems of mice included weight change of the test mice, SOD activity of blood red cells, and MDA content, SOD and GSH-Px activities of liver before and after treatment with 8Gy60Coγray. The results showed that there were no significant differences in effects of different doses capsule on liver SOD activity. 75 mg/kg?bw and 150 mg/kg?bw capsule had no significant effects on MDA content and GSH-Px activity of liver. But 300 mg/kg?bw capsule significantly decreased MDA content (132.9±19.4 VS 170.1±22.9) and increased GSH-Px activity (23.0±2.64 VS 19.1±2.97) of liver compared with control group. It will provide a reference for comprehensive application of tea polyphenol, VE and selenium in health foods.