山西医药杂志
山西醫藥雜誌
산서의약잡지
SHANXI MEDICAL JOURNAL
2014年
12期
1362-1363,1364
,共3页
韦杏%陈自仁%赵芳%张黎美%刘爱民%程琦%刘罗进
韋杏%陳自仁%趙芳%張黎美%劉愛民%程琦%劉囉進
위행%진자인%조방%장려미%류애민%정기%류라진
狼疮肾炎%泼尼松龙%黄葵属
狼瘡腎炎%潑尼鬆龍%黃葵屬
랑창신염%발니송룡%황규속
Lupus nephritis%Prednisolone%Abelmoschus
目的:研究黄葵胶囊对Ⅲ~Ⅴ型狼疮肾炎(LN)的疗效。方法56例Ⅲ~Ⅴ型LN患者,所有入选患者均行肾活检,随机分为2组,试验组28例,对照组28例,对照组给予中等量激素(泼尼松1mg·kg-1·d-1)、辛伐他汀调脂、贝那普利降低蛋白尿、奥美拉唑护胃等一般治疗,其中Ⅳ~Ⅴ型L N患者开始3 d予甲泼尼松龙(10 mg·kg -1·d-1)连续冲击治疗3d,后定期每月予环磷酰胺(0.8~1.0g)静脉冲击治疗1次,连续8次。试验组在对照组治疗基础上加用黄葵胶囊治疗。6个月后复查试验组和对照组各项实验室指标并比较分析。结果试验组总体治疗有效率(93%)高于对照组(71%)( P <0.05),治疗后试验组血脂、尿蛋白定量(24 h )及红细胞沉降率(ESR)均明显低于对照组( P<0.05),血浆白蛋白(ALB)及补体C3均高于对照组( P <0.05)。结论黄葵胶囊治疗LN有效,有明显改善作用。
目的:研究黃葵膠囊對Ⅲ~Ⅴ型狼瘡腎炎(LN)的療效。方法56例Ⅲ~Ⅴ型LN患者,所有入選患者均行腎活檢,隨機分為2組,試驗組28例,對照組28例,對照組給予中等量激素(潑尼鬆1mg·kg-1·d-1)、辛伐他汀調脂、貝那普利降低蛋白尿、奧美拉唑護胃等一般治療,其中Ⅳ~Ⅴ型L N患者開始3 d予甲潑尼鬆龍(10 mg·kg -1·d-1)連續遲擊治療3d,後定期每月予環燐酰胺(0.8~1.0g)靜脈遲擊治療1次,連續8次。試驗組在對照組治療基礎上加用黃葵膠囊治療。6箇月後複查試驗組和對照組各項實驗室指標併比較分析。結果試驗組總體治療有效率(93%)高于對照組(71%)( P <0.05),治療後試驗組血脂、尿蛋白定量(24 h )及紅細胞沉降率(ESR)均明顯低于對照組( P<0.05),血漿白蛋白(ALB)及補體C3均高于對照組( P <0.05)。結論黃葵膠囊治療LN有效,有明顯改善作用。
목적:연구황규효낭대Ⅲ~Ⅴ형랑창신염(LN)적료효。방법56례Ⅲ~Ⅴ형LN환자,소유입선환자균행신활검,수궤분위2조,시험조28례,대조조28례,대조조급여중등량격소(발니송1mg·kg-1·d-1)、신벌타정조지、패나보리강저단백뇨、오미랍서호위등일반치료,기중Ⅳ~Ⅴ형L N환자개시3 d여갑발니송룡(10 mg·kg -1·d-1)련속충격치료3d,후정기매월여배린선알(0.8~1.0g)정맥충격치료1차,련속8차。시험조재대조조치료기출상가용황규효낭치료。6개월후복사시험조화대조조각항실험실지표병비교분석。결과시험조총체치료유효솔(93%)고우대조조(71%)( P <0.05),치료후시험조혈지、뇨단백정량(24 h )급홍세포침강솔(ESR)균명현저우대조조( P<0.05),혈장백단백(ALB)급보체C3균고우대조조( P <0.05)。결론황규효낭치료LN유효,유명현개선작용。
Objective To study the effects of Huangkui capsule on the treatment of type Ⅲ-Ⅴ lupus ne-phritis(LN) patients.Methods Fifty-six patients of type Ⅲ-Ⅴ LN were randomly divided into two groups ,each group had 28 cases .The control group patients were treated with prednisone (1 mg · kg -1 · d-1 ) ,simvastatin , benazepril and omeprazole and type Ⅳ-Ⅴ LN patients were given methylprednisolone (10 mg · kg -1 · d-1 ) pound treatment for three days and cyclophosphamide (0 .8-1 .0)g vein injection every month for 8 months .The experi-mental group patients were added Huangkui capsule treatment additionally .The laboratory indexes were measured at baseline and 4 weeks after treatment .Results The total effective rate of the experimental group (93% )was higher than that of the control group (71% )( P<0 .05) .The level of lipid ,24 h urine protein and ESR of the ex-perimental group were obviously reduced than those of the control group ( P<0 .05) ,and the level of ALB and C3 of the experimental group were higher than that of the control group ( P <0 .05) .Conclusion Huangkui capsule treatment for LN patients is effective.