CAJ | 학술논문

目的：研究黄葵胶囊对Ⅲ～Ⅴ型狼疮肾炎（LN）的疗效。方法56例Ⅲ～Ⅴ型LN患者，所有入选患者均行肾活检，随机分为2组，试验组28例，对照组28例，对照组给予中等量激素（泼尼松1mg·kg-1·d-1）、辛伐他汀调脂、贝那普利降低蛋白尿、奥美拉唑护胃等一般治疗，其中Ⅳ～Ⅴ型L N患者开始3 d予甲泼尼松龙（10 mg·kg -1·d-1）连续冲击治疗3d，后定期每月予环磷酰胺（0．8～1．0g）静脉冲击治疗1次，连续8次。试验组在对照组治疗基础上加用黄葵胶囊治疗。6个月后复查试验组和对照组各项实验室指标并比较分析。结果试验组总体治疗有效率（93％）高于对照组（71％）（ P ＜0．05），治疗后试验组血脂、尿蛋白定量（24 h ）及红细胞沉降率（ESR）均明显低于对照组（ P＜0．05），血浆白蛋白（ALB）及补体C3均高于对照组（ P ＜0．05）。结论黄葵胶囊治疗LN有效，有明显改善作用。
목적：연구황규효낭대Ⅲ～Ⅴ형랑창신염（LN）적료효。방법56례Ⅲ～Ⅴ형LN환자，소유입선환자균행신활검，수궤분위2조，시험조28례，대조조28례，대조조급여중등량격소（발니송1mg·kg-1·d-1）、신벌타정조지、패나보리강저단백뇨、오미랍서호위등일반치료，기중Ⅳ～Ⅴ형L N환자개시3 d여갑발니송룡（10 mg·kg -1·d-1）련속충격치료3d，후정기매월여배린선알（0．8～1．0g）정맥충격치료1차，련속8차。시험조재대조조치료기출상가용황규효낭치료。6개월후복사시험조화대조조각항실험실지표병비교분석。결과시험조총체치료유효솔（93％）고우대조조（71％）（ P ＜0．05），치료후시험조혈지、뇨단백정량（24 h ）급홍세포침강솔（ESR）균명현저우대조조（ P＜0．05），혈장백단백（ALB）급보체C3균고우대조조（ P ＜0．05）。결론황규효낭치료LN유효，유명현개선작용。
Objective To study the effects of Huangkui capsule on the treatment of type Ⅲ-Ⅴ lupus ne-phritis(LN) patients.Methods Fifty-six patients of type Ⅲ-Ⅴ LN were randomly divided into two groups ,each group had 28 cases .The control group patients were treated with prednisone (1 mg · kg -1 · d-1 ) ,simvastatin , benazepril and omeprazole and type Ⅳ-Ⅴ LN patients were given methylprednisolone (10 mg · kg -1 · d-1 ) pound treatment for three days and cyclophosphamide (0 .8-1 .0)g vein injection every month for 8 months .The experi-mental group patients were added Huangkui capsule treatment additionally .The laboratory indexes were measured at baseline and 4 weeks after treatment .Results The total effective rate of the experimental group (93% )was higher than that of the control group (71% )( P<0 .05) .The level of lipid ,24 h urine protein and ESR of the ex-perimental group were obviously reduced than those of the control group ( P<0 .05) ,and the level of ALB and C3 of the experimental group were higher than that of the control group ( P <0 .05) .Conclusion Huangkui capsule treatment for LN patients is effective.