CAJ | 학술논문

前哨淋巴结活检（sentinel lymph node biopsy，SLNB）是皮肤恶性黑色素瘤诊治过程中不可或缺的手段，在进行准确分期、预后判断以及治疗指导等方面都发挥着重要的作用。SLNB的操作方法已基本成熟，但在适应症的选择方面还存在一定的争议，仍无足够的证据表明前哨淋巴结活检联合区域淋巴结清扫（complete lymph node biopsy，CLND）能够延长转移患者的生存。此外，由于国内恶性黑色素瘤的发病率较低，SLNB尚未得到广泛开展，相关的操作方法也较为落后。近年来，随着恶性黑色素瘤发病率增高，其外科治疗也受到越来越多的关注。本文通过总结分析近年来的相关文献，对SLNB在皮肤恶性黑色素瘤中的应用现状和进展进行综述。
전초림파결활검（sentinel lymph node biopsy，SLNB）시피부악성흑색소류진치과정중불가혹결적수단，재진행준학분기、예후판단이급치료지도등방면도발휘착중요적작용。SLNB적조작방법이기본성숙，단재괄응증적선택방면환존재일정적쟁의，잉무족구적증거표명전초림파결활검연합구역림파결청소（complete lymph node biopsy，CLND）능구연장전이환자적생존。차외，유우국내악성흑색소류적발병솔교저，SLNB상미득도엄범개전，상관적조작방법야교위락후。근년래，수착악성흑색소류발병솔증고，기외과치료야수도월래월다적관주。본문통과총결분석근년래적상관문헌，대SLNB재피부악성흑색소류중적응용현상화진전진행종술。
Sentinel lymph node biopsy has a very important function in the accurate staging, diagnosis, and treatment of malig-nant melanoma. The operational technique of sentinel lymph node biopsy (SLNB) has been basically mature, but its indications remain unclear, especially for thin melanomas. Adequate evidence to show that SLNB combined with a complete lymph node dissection can prolong the survival of patients with metastasis is unavailable. Given the low incidence of malignant melanoma in the country, the use of SLNB has not been extensively investigated in China and the relevant methods are outdated. This review summarizes the current ap-plication of SLNB in cutaneous malignant melanoma by analyzing related studies conducted in recent years.